508147 RS 127445 Hydrochloride - CAS 199864-86-3 - Calbiochem

508147
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₆FN₃·HCl 199864-86-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08147.0001
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          Glass bottle 10 mg
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          Description
          OverviewA selective, high affinity , orally bioavailable 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites including the closely related 5-HT2A and 5-HT2C receptors. In isolated human cells, RS-127445 exbhited an IC50 greater than 10 µM.
          Catalogue Number508147
          Brand Family Calbiochem®
          References
          ReferencesSharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther. 22, 389.
          Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
          Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
          Product Information
          CAS number199864-86-3
          FormOff-white solid
          Hill FormulaC₁₇H₁₆FN₃·HCl
          Chemical formulaC₁₇H₁₆FN₃·HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-HT2B
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Sharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther. 22, 389.
          Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
          Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-October-2013 JSW
          DescriptionA selective, high affinity , orally bioavailable 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites including the closely related 5-HT2A and 5-HT2C receptors. In isolated human cells, RS-127445 exbhited an IC50 greater than 10 µM.
          FormOff-white solid
          CAS number199864-86-3
          Chemical formulaC₁₇H₁₆FN₃·HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mM) or Ethanol (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther. 22, 389.
          Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
          Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.