504376 RS 102895 hydrochloride - CAS 300815-41-2 - Calbiochem

504376
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₁F₃N₂O₂•HCl 300815-41-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04376.0001
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          Glass bottle 5 mg
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          Description
          OverviewA selective antagonist for CCR2 receptors (IC50 = 0.36 and 17.8 µM for CCR2b and CCR1 receptors, respectively). Blocks monocyte chemoattractant protein-1 induced calcium influx and chemotaxis (IC50 = 32 nM and 1.7 µM respectively). A potential anti-inflammatory therapeutic agent by Inhibiting α1A, α1D and 5-HT1A receptors.
          Catalogue Number504376
          Brand Family Calbiochem®
          Synonyms1ʹ-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4ʹ-piperidin]-2(1H)-one hydrochloride, RS 102895, RS102895
          References
          ReferencesLee, Y., 2010. Magnetic Resonance in Medicine. 64, 72.
          Clark, R.D., et al. 1983. J. Med. Chem. 26, 657.
          Mirzadegan, T., et al. 2000. J. Biol. Chem. 275, 5562.
          Mitchell, L., et al. 2012. Int. Immunopharmacol. 15, 357.
          Product Information
          CAS number300815-41-2
          FormOff-white powder
          Hill FormulaC₂₁H₂₁F₃N₂O₂•HCl
          Chemical formulaC₂₁H₂₁F₃N₂O₂•HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCCR2
          Primary Target IC<sub>50</sub>0.36 and 17.8 µM for human recombinant CCR2b and CCR1 receptors, respectively.
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Lee, Y., 2010. Magnetic Resonance in Medicine. 64, 72.
          Clark, R.D., et al. 1983. J. Med. Chem. 26, 657.
          Mirzadegan, T., et al. 2000. J. Biol. Chem. 275, 5562.
          Mitchell, L., et al. 2012. Int. Immunopharmacol. 15, 357.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-June-2013 JSW
          Synonyms1ʹ-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4ʹ-piperidin]-2(1H)-one hydrochloride, RS 102895, RS102895
          DescriptionA selective antagonist for CCR2 receptors (IC50 = 0.36 and 17.8 µM for CCR2b and CCR1 receptors, respectively). Blocks monocyte chemoattractant protein-1 induced calcium influx and chemotaxis (IC50 = 32 nM and 1.7 µM respectively). A potential anti-inflammatory therapeutic agent by Inhibiting α1A, α1D and 5-HT1A receptors.
          FormOff-white powder
          CAS number300815-41-2
          Chemical formulaC₂₁H₂₁F₃N₂O₂•HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLee, Y., 2010. Magnetic Resonance in Medicine. 64, 72.
          Clark, R.D., et al. 1983. J. Med. Chem. 26, 657.
          Mirzadegan, T., et al. 2000. J. Biol. Chem. 275, 5562.
          Mitchell, L., et al. 2012. Int. Immunopharmacol. 15, 357.