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554994 | RHC-80267 - CAS 83654-05-1 - Calbiochem

554994
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₃₄N₄O₄ 83654-05-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      554994-10MG
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          Glass bottle 10 mg
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          Description
          OverviewSelective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.
          Catalogue Number554994
          Brand Family Calbiochem®
          Synonyms1,6-bis(Cyclohexyloximinocarbonylamino)hexane
          References
          ReferencesShinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295.
          Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.
          Konrad, R.J., et al. 1994. Biochemistry 33, 13284.
          Mason-Garcia, M., et al. 1992. Am. J. Physiol. 262, C1197.
          Balsinde, J., et al. 1991. J. Biol. Chem. 266, 15638.
          Product Information
          CAS number83654-05-1
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₂₀H₃₄N₄O₄
          Chemical formulaC₂₀H₃₄N₄O₄
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetDAG lipase
          Primary Target IC<sub>50</sub>4 nM against DAG lipase activity in canine platelets
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          554994

          References

          Reference overview
          Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295.
          Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.
          Konrad, R.J., et al. 1994. Biochemistry 33, 13284.
          Mason-Garcia, M., et al. 1992. Am. J. Physiol. 262, C1197.
          Balsinde, J., et al. 1991. J. Biol. Chem. 266, 15638.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          Synonyms1,6-bis(Cyclohexyloximinocarbonylamino)hexane
          DescriptionSelective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II and ATP-induced synthesis of 6-keto-prostaglandin F1α.
          FormWhite to off-white solid
          CAS number83654-05-1
          Chemical formulaC₂₀H₃₄N₄O₄
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (25 mg/ml) or ethanol (25 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesShinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295.
          Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.
          Konrad, R.J., et al. 1994. Biochemistry 33, 13284.
          Mason-Garcia, M., et al. 1992. Am. J. Physiol. 262, C1197.
          Balsinde, J., et al. 1991. J. Biol. Chem. 266, 15638.