553030 RAGE Antagonist, FPS-ZM1 - Calbiochem

553030
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₀H₂₂ClNO

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      553030-25MG
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      Stocked 
      Discontinued
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      Available
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          Glass bottle 25 mg
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          Description
          OverviewA blood-brain-barrier-permeant, non-toxic, tertiary amide compound that acts as a high affinity, potent, multimodal blocker of RAGE (Receptor for Advanced Glycation End products) V domain-mediated ligand binding (Ki = 25, 148, and 230 nM, respectively, against Aβ40, HMGB1, and S100B, binding to sRAGE). Blocks RAGE-mediated influx of Aβ40 and Aβ42 into the brain. Also shown to suppress Aβ-RAGE induced NF-κB activation and NF-κB-dependent transcription of β-secretase. Daily treatment of APPsw/0 murine AD model (1 mg/kg/d via i.p.) is reported to greatly reduce Thioflavin S-positive amyloid plaques in cortex and hippocampus (by 70 to 80%) and restore congnitive performance to the level of non-AD mice.
          Catalogue Number553030
          Brand Family Calbiochem®
          SynonymsN-Benzyl-4-chloro-N-cyclohexylbenzamide, Receptor for AGE Antagonist, FPS-ZM1
          References
          ReferencesDeane, R., et al. 2012. J. Clin. Invest. 122, 1377.
          Product Information
          FormWhite to off-white semi-solid or viscous liquid
          Hill FormulaC₂₀H₂₂ClNO
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetRAGE
          Primary Target K<sub>i</sub>25, 148, and 230 nM, respectively, against A&beta
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          RAGE Antagonist, FPS-ZM1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          RAGE Antagonist, FPS-ZM1 - Calbiochem Certificates of Analysis

          TitleLot Number
          553030

          References

          Reference overview
          Deane, R., et al. 2012. J. Clin. Invest. 122, 1377.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-June-2017 JSW
          SynonymsN-Benzyl-4-chloro-N-cyclohexylbenzamide, Receptor for AGE Antagonist, FPS-ZM1
          DescriptionA blood-brain-barrier-permeant, non-toxic, tertiary amide compound that acts as a high affinity, potent, multimodal blocker of RAGE (Receptor for Advanced Glycation End products) V domain-mediated ligand binding (Ki = 25, 148, and 230 nM, respectively, against Aβ40, HMGB1, and S100B, binding to sRAGE). Blocks RAGE-mediated influx of Aβ40 and Aβ42 into the brain. Also shown to suppress Aβ-RAGE induced NF-κB activation and NF-κB-dependent transcription of β-secretase. Daily treatment of APPsw/0 murine AD model (1 mg/kg/d via i.p.) is reported to greatly reduce Thioflavin S-positive amyloid plaques in cortex and hippocampus (by 70 to 80%) and restore congnitive performance to the level of non-AD mice.
          FormWhite to off-white semi-solid or viscous liquid
          Intert gas (Yes/No) Packaged under inert gas
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesDeane, R., et al. 2012. J. Clin. Invest. 122, 1377.