553525 RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem

553525
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₁₇N₃O 1290541-46-6

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      553525-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50 = 27.4 µM). Does not affect RecA even at much higher concentration (~250 µM). Directly interacts with RAD51 (Kd = 5.6 µM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin (Cat. No. 232120) and Mitomycin C (Cat. No. 47589), (Cat. No. 475820). Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 (Cat. No. 553510) is also available.
          Catalogue Number553525
          Brand Family Calbiochem®
          Synonyms(E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one
          References
          ReferencesHuang, F., et al. 2012. J. Med. Chem. 55, 3031.
          Huang, F., et al. 2011. ACS Chem. Biol. 6, 628.
          Product Information
          CAS number1290541-46-6
          FormLight yellow powder
          Hill FormulaC₂₂H₁₇N₃O
          Chemical formulaC₂₂H₁₇N₃O
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          553525

          References

          Reference overview
          Huang, F., et al. 2012. J. Med. Chem. 55, 3031.
          Huang, F., et al. 2011. ACS Chem. Biol. 6, 628.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-September-2013 JSW
          Synonyms(E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one
          DescriptionA cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50 = 27.4 µM). Does not affect RecA even at much higher concentration (~250 µM). Directly interacts with RAD51 (Kd = 5.6 µM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin (Cat. No. 232120) and Mitomycin C (Cat. No. 47589), (Cat. No. 475820). Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 (Cat. No. 553510) is also available.
          FormLight yellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1290541-46-6
          Chemical formulaC₂₂H₁₇N₃O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesHuang, F., et al. 2012. J. Med. Chem. 55, 3031.
          Huang, F., et al. 2011. ACS Chem. Biol. 6, 628.