551600 Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem

551600
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₀O₇ · 2H₂O 6151-25-3

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      551600-100MG
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          Glass bottle 100 mg
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          Description
          OverviewA cell-permeable and reversible inhibitor of PIM1 kinase (IC50 = 43 nM), PI 3-K (IC50 = 3.8 µM) and phospholipase A2 (IC50 = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.
          Catalogue Number551600
          Brand Family Calbiochem®
          Synonyms3,3ʹ,4ʹ,5,7-Pentahydroxyflavone
          References
          ReferencesBullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
          Howitz, K.T., et al. 2003. Nature 425, 191.
          Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
          Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
          Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
          Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
          Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
          Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
          Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
          Beretz, A., et al. 1978. Experientia 34, 1054.
          Product Information
          CAS number6151-25-3
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₅H₁₀O₇ · 2H₂O
          Chemical formulaC₁₅H₁₀O₇ · 2H₂O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPI 3-kinase
          Primary Target IC<sub>50</sub>43 nM, 3.8 µM, 2 µM against PIM1 kinase, PI 3-K, and phospholipase A2, respectively
          Purity>95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSLK8950000
          Safety Information
          R PhraseR: 25-40

          Toxic if swallowed.
          Limited evidence of a carcinogenic effect.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          551600

          References

          Reference overview
          Bullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
          Howitz, K.T., et al. 2003. Nature 425, 191.
          Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
          Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
          Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
          Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
          Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
          Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
          Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
          Beretz, A., et al. 1978. Experientia 34, 1054.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-June-2009 JSW
          Synonyms3,3ʹ,4ʹ,5,7-Pentahydroxyflavone
          DescriptionA cell-permeable inhibitor of PIM1 kinase (IC50 = 43 nM), PI 3-K (IC50 = 3.8 µM) and phospholipase A2 (IC50 = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.
          FormYellow solid
          CAS number6151-25-3
          RTECSLK8950000
          Chemical formulaC₁₅H₁₀O₇ · 2H₂O
          Structure formulaStructure formula
          Purity>95% by HPLC
          SolubilityAcetic Acid (1 mg/ml), Aqueous Alkali (1 mg/ml), or DMSO (5 mg/ml)
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
          Toxicity Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 8034
          ReferencesBullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
          Howitz, K.T., et al. 2003. Nature 425, 191.
          Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
          Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
          Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
          Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
          Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
          Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
          Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
          Beretz, A., et al. 1978. Experientia 34, 1054.