504535 | QNZ46 - CAS 1237744-13-6 - Calbiochem

504535
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₁₇N₃O₆ 1237744-13-6

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04535.0001
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          Glass bottle 5 mg
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          Description
          OverviewA noncompetitive and voltage-independent antagonist selective for NR2C/D containing NMDA receptors (IC50 = 6, 3, 229, and >300 µM for NR2C, NR2D, NR2A, and NR2B, respectively). Inhibition on NR2C/D containing NMDA receptors is glutamate-binding, but not glycine-binding, dependent. Represents a new class of noncompetitive subunit-selective NMDA receptor antagonists. With more than 100-fold selectivity for recombinant NMDA receptors over AMPA and kainate receptors.
          Catalogue Number504535
          Brand Family Calbiochem®
          Synonyms4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid, NMDA Antagonist VIII
          References
          ReferencesMayer, M., et al. 2013. Annu. Rev. Physiol. 75, 1.
          Hansen, K., 2011. J. Neurosci. 9, 3650.
          Mosley, C., et al. 2010. J. Med. Chem. 53, 5476.
          Product Information
          CAS number1237744-13-6
          FormYellow powder
          Hill FormulaC₂₄H₁₇N₃O₆
          Chemical formulaC₂₄H₁₇N₃O₆
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNMDA receptors
          Primary Target IC<sub>50</sub>6, 3, 229, and >300 →M for NR2C, NR2D, NR2A, and NR2B, respectively.
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Mayer, M., et al. 2013. Annu. Rev. Physiol. 75, 1.
          Hansen, K., 2011. J. Neurosci. 9, 3650.
          Mosley, C., et al. 2010. J. Med. Chem. 53, 5476.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-June-2013 JSW
          Synonyms4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid, NMDA Antagonist VIII
          DescriptionA noncompetitive and voltage-independent antagonist selective for NR2C/D containing NMDA receptors (IC50 = 6, 3, 229, and >300 µM for NR2C, NR2D, NR2A, and NR2B, respectively). Inhibition on NR2C/D containing NMDA receptors is glutamate-binding, but not glycine-binding, dependent. Represents a new class of noncompetitive subunit-selective NMDA receptor antagonists. With more than 100-fold selectivity for recombinant NMDA receptors over AMPA and kainate receptors.
          FormYellow powder
          CAS number1237744-13-6
          Chemical formulaC₂₄H₁₇N₃O₆
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml). Slight warming is required for complete solubilization.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMayer, M., et al. 2013. Annu. Rev. Physiol. 75, 1.
          Hansen, K., 2011. J. Neurosci. 9, 3650.
          Mosley, C., et al. 2010. J. Med. Chem. 53, 5476.