540220 Purmorphamine - CAS 483367-10-8 - Calbiochem

540220
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₁H₃₂N₆O₂ 483367-10-8

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      540220-20MG
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          Glass bottle 20 mg
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          540220-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 µM) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4) and has been shown to induce transdifferentiation even in preadipocytes and myoblasts. Reported to induce osteogenesis by activation of the Hedgehog signaling pathway. A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540223) in DMSO is also available.

              Please note that the molecular weight for this compound is batch-specific due to variable water content.
              Catalogue Number540220
              Brand Family Calbiochem®
              Synonyms2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
              References
              ReferencesWu, X., et al. 2004. Chem. Biol. 11, 1229.
              Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.
              Product Information
              CAS number483367-10-8
              ATP CompetitiveN
              FormOff-white solid
              Hill FormulaC₃₁H₃₂N₆O₂
              Chemical formulaC₃₁H₃₂N₆O₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetActivation of the Hedgehog signaling pathway
              Primary Target IC<sub>50</sub>EC50 = 1 µM for inducing osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 22-68

              Harmful if swallowed.
              Possible risks of irreversible effects.
              S PhraseS: 22-36/37

              Do not breathe dust.
              Wear suitable protective clothing and gloves.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Purmorphamine - CAS 483367-10-8 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Purmorphamine - CAS 483367-10-8 - Calbiochem Certificates of Analysis

              TitleLot Number
              540220

              References

              Reference overview
              Wu, X., et al. 2004. Chem. Biol. 11, 1229.
              Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.

              Brochure

              Title
              Biologics 33.2
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision21-November-2014 JSW
              Synonyms2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
              DescriptionA cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC50 = 1 µM) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.
              FormOff-white solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number483367-10-8
              Chemical formulaC₃₁H₃₂N₆O₂
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (200 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Harmful
              ReferencesWu, X., et al. 2004. Chem. Biol. 11, 1229.
              Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.