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539690 | Protein Synthesis Initiation Inhibitor, NSC 119889 - Calbiochem

539690
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₀H₈Br₄O₅

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      539690-25MG
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      Stocked 
      Discontinued
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      Available
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
          Catalogue Number539690
          Brand Family Calbiochem®
          Synonyms3,4,5,6-Tetrabromofluorescein
          References
          ReferencesNovac, O., et al. 2004. Nucleic Acids Res. 32, 902.
          Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.
          Product Information
          ATP CompetitiveN
          FormLight brown solid
          Hill FormulaC₂₀H₈Br₄O₅
          Chemical formulaC₂₀H₈Br₄O₅
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary Targethuman arginine methyl transferase
          Primary Target IC<sub>50</sub>1.41 µM against human arginine methyl transferase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          539690

          References

          Reference overview
          Novac, O., et al. 2004. Nucleic Acids Res. 32, 902.
          Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-September-2007 JSW
          Synonyms3,4,5,6-Tetrabromofluorescein
          DescriptionA cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5'-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
          FormLight brown solid
          Chemical formulaC₂₀H₈Br₄O₅
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml) or Methanol
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesNovac, O., et al. 2004. Nucleic Acids Res. 32, 902.
          Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.