537009 Progranulin, CF, Mouse, Recombinant

537009
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥90% by SDS-PAGE

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      537009-50UG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Glass bottle 50 μg
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          Description
          OverviewRecombinant, mouse progranulin, consisting of amino acids 18-589, fused at the C-terminus to a His•Tag® sequence, and expressed in NS0-derived mouse myeloma cells. Progranulin is an ubiquitously expressed, secreted glycoprotein that is involved in regulation of cell proliferation.
          Catalogue Number537009
          Brand Family Calbiochem®
          SynonymsPC cell-derived growth factor (PCDGF)
          References
          ReferencesLiu, Y. et al. 2007. BMC Cancer 7, 22.
          Xu, K. et al. 2007. J. Biol. Chem. 282, 11347.
          Barreda, D.R. et al. 2004. Dev. Comp. Immunol. 28, 727.
          Davidson, B. et al. 2004. Cancer 100, 2139.
          Sun, X. et al. 2004. Am. J. Respir. Cell Mol. Biol. 30, 510.
          Gonzalez, E.M. et al. 2003. J. Biol. Chem. 278, 38113.
          He, Z. et al. 2003. Nat. Med. 9, 225.
          He, Z. and Bateman, A. 2003. J. Mol. Med. 81, 600.
          Jones, M.B. et al. 2003. Gynecol. Oncol. 88, S136.
          Wang, W. et al. 2003. Clin. Cancer Res. 9, 2221.
          Suzuki, M. and Nishiahara, M. 2002. Mol. Genet. Metab. 75, 31.
          Zhu, J. et al. 2002. Cell 111, 867.
          Lu, R. and Serrero, G. 2000. Proc. Natl. Acad. Sci. U.S.A. 97, 3993.
          Justen, H.P. et al. 2000. Mol. Cell Biol. Res. Commun. 3, 165.
          Zanocco Marani, T. et al. 1999. Cancer Res. 59, 5331.
          Zhang, H. and G. Serrero 1998. Proc. Natl. Acad. Sci. U.S.A. 95, 14202.
          Zhou, J. et al. 1993. J. Biol. Chem. 268, 10863.
          Plowman, G.D. et al. 1992. J. Biol. Chem. 267, 13073.
          Bateman, A. et al. 1990. Biochem. Biophys. Res. Commun. 173, 1161.
          Product Information
          FormLyophilized
          FormulationLyophilized from 0.2 µm filtered PBS.
          Applications
          Biological Information
          Biological activitySignificantly enhances neurite outgrowth of E18 rat embryonic cortical neurons using 4-16 µg/ml progranulin immobilized on nitrocelluose-coated microplates.
          Purity≥90% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: ≤1.0 EU/µg protein
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Progranulin, CF, Mouse, Recombinant SDS

          Title

          Safety Data Sheet (SDS) 

          Progranulin, CF, Mouse, Recombinant Certificates of Analysis

          TitleLot Number
          537009

          References

          Reference overview
          Liu, Y. et al. 2007. BMC Cancer 7, 22.
          Xu, K. et al. 2007. J. Biol. Chem. 282, 11347.
          Barreda, D.R. et al. 2004. Dev. Comp. Immunol. 28, 727.
          Davidson, B. et al. 2004. Cancer 100, 2139.
          Sun, X. et al. 2004. Am. J. Respir. Cell Mol. Biol. 30, 510.
          Gonzalez, E.M. et al. 2003. J. Biol. Chem. 278, 38113.
          He, Z. et al. 2003. Nat. Med. 9, 225.
          He, Z. and Bateman, A. 2003. J. Mol. Med. 81, 600.
          Jones, M.B. et al. 2003. Gynecol. Oncol. 88, S136.
          Wang, W. et al. 2003. Clin. Cancer Res. 9, 2221.
          Suzuki, M. and Nishiahara, M. 2002. Mol. Genet. Metab. 75, 31.
          Zhu, J. et al. 2002. Cell 111, 867.
          Lu, R. and Serrero, G. 2000. Proc. Natl. Acad. Sci. U.S.A. 97, 3993.
          Justen, H.P. et al. 2000. Mol. Cell Biol. Res. Commun. 3, 165.
          Zanocco Marani, T. et al. 1999. Cancer Res. 59, 5331.
          Zhang, H. and G. Serrero 1998. Proc. Natl. Acad. Sci. U.S.A. 95, 14202.
          Zhou, J. et al. 1993. J. Biol. Chem. 268, 10863.
          Plowman, G.D. et al. 1992. J. Biol. Chem. 267, 13073.
          Bateman, A. et al. 1990. Biochem. Biophys. Res. Commun. 173, 1161.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-June-2011 RFH
          SynonymsPC cell-derived growth factor (PCDGF)
          DescriptionRecombinant, mouse progranulin, consisting of amino acids 18-589, fused at the C-terminus to a His•Tag® sequence, and expressed in NS0-derived mouse myeloma cells. Progranulin is an ubiquitously expressed, secreted glycoprotein that is involved in regulation of cell proliferation.
          FormLyophilized
          FormulationLyophilized from 0.2 µm filtered PBS.
          Purity≥90% by SDS-PAGE
          ContaminantsEndotoxin: ≤1.0 EU/µg protein
          Biological activitySignificantly enhances neurite outgrowth of E18 rat embryonic cortical neurons using 4-16 µg/ml progranulin immobilized on nitrocelluose-coated microplates.
          SolubilityReconstitute to 250 µg/ml with sterile PBS.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLiu, Y. et al. 2007. BMC Cancer 7, 22.
          Xu, K. et al. 2007. J. Biol. Chem. 282, 11347.
          Barreda, D.R. et al. 2004. Dev. Comp. Immunol. 28, 727.
          Davidson, B. et al. 2004. Cancer 100, 2139.
          Sun, X. et al. 2004. Am. J. Respir. Cell Mol. Biol. 30, 510.
          Gonzalez, E.M. et al. 2003. J. Biol. Chem. 278, 38113.
          He, Z. et al. 2003. Nat. Med. 9, 225.
          He, Z. and Bateman, A. 2003. J. Mol. Med. 81, 600.
          Jones, M.B. et al. 2003. Gynecol. Oncol. 88, S136.
          Wang, W. et al. 2003. Clin. Cancer Res. 9, 2221.
          Suzuki, M. and Nishiahara, M. 2002. Mol. Genet. Metab. 75, 31.
          Zhu, J. et al. 2002. Cell 111, 867.
          Lu, R. and Serrero, G. 2000. Proc. Natl. Acad. Sci. U.S.A. 97, 3993.
          Justen, H.P. et al. 2000. Mol. Cell Biol. Res. Commun. 3, 165.
          Zanocco Marani, T. et al. 1999. Cancer Res. 59, 5331.
          Zhang, H. and G. Serrero 1998. Proc. Natl. Acad. Sci. U.S.A. 95, 14202.
          Zhou, J. et al. 1993. J. Biol. Chem. 268, 10863.
          Plowman, G.D. et al. 1992. J. Biol. Chem. 267, 13073.
          Bateman, A. et al. 1990. Biochem. Biophys. Res. Commun. 173, 1161.