528281 Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem

528281
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₂₇ClN₂O₄ 775294-82-1

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      528281-10MG
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          10 mg
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          Description
          OverviewA cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM.
          Catalogue Number528281
          Brand Family Calbiochem®
          SynonymsN-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
          References
          ReferencesKeppner, S., et al. 2009. ChemMedChem. 4, 1806.
          Product Information
          CAS number775294-82-1
          FormBeige solid
          Hill FormulaC₂₄H₂₇ClN₂O₄
          Chemical formulaC₂₄H₂₇ClN₂O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥94% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          528281

          References

          Reference overview
          Keppner, S., et al. 2009. ChemMedChem. 4, 1806.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-April-2011 RFH
          SynonymsN-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
          DescriptionA cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM.
          FormBeige solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number775294-82-1
          Chemical formulaC₂₄H₂₇ClN₂O₄
          Structure formulaStructure formula
          Purity≥94% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKeppner, S., et al. 2009. ChemMedChem. 4, 1806.