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528284 | Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem

528284
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₁₈F₃N₃O₄S 660868-91-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      528284-500UG
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          Glass bottle 500 μg
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          Description
          OverviewA cell-permeable thiophene-benzimidazole compound that acts as a potent and reversible inhibitor against polo-like kinases (K i against Plk1/2/3/4 = 4.8, 3.8, 8.0, and 163 nM , respectively), while exhibiting little or much reduced activity against 39 other commonly studied kinases. Preferentially inhibits the proliferation of a panel of 11 tumor cell lines (IC50 ≤0.7 µM) over normal human diploid fibroblasts (IC50 = 6.14 µM) in culture and is equally potent against the mdr-1-expressing MES-SA/DX5 and its parent non-drug resistant MES-SA uterine sarcoma cell line.
          Catalogue Number528284
          Brand Family Calbiochem®
          Synonyms5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)-benzyl)oxy)thiophene-2-carboxamide, Plk Inhibitor III
          References
          ReferencesJohnson, E.F., et al. 2007. Biochemistry 46, 9551.
          Lansing, T.J., et al. 2007. Mol. Cancer Ther. 6, 450.
          Product Information
          CAS number660868-91-7
          FormOff-white solid
          Hill FormulaC₂₂H₁₈F₃N₃O₄S
          Chemical formulaC₂₂H₁₈F₃N₃O₄S
          Structure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36/37-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          528284

          References

          Reference overview
          Johnson, E.F., et al. 2007. Biochemistry 46, 9551.
          Lansing, T.J., et al. 2007. Mol. Cancer Ther. 6, 450.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-May-2009 RFH
          Synonyms5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)-benzyl)oxy)thiophene-2-carboxamide, Plk Inhibitor III
          DescriptionA cell-permeable thiophene-benzimidazole compound that acts as a potent and reversible inhibitor against polo-like kinases (K i against Plk1/2/3/4 = 4.8, 3.8, 8.0, and 163 nM, respectively), while exhibiting little or much reduced activity against 39 other commonly studied kinases. Preferentially inhibits the proliferation of a panel of 11 tumor cell lines (IC50 ≤0.7 µM) over normal human diploid fibroblasts (IC50 = 6.14 µM) in culture and is equally potent against the mdr-1-expressing MES-SA/DX5 and its parent non-drug resistant MES-SA uterine sarcoma cell line.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number660868-91-7
          Chemical formulaC₂₂H₁₈F₃N₃O₄S
          Structure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesJohnson, E.F., et al. 2007. Biochemistry 46, 9551.
          Lansing, T.J., et al. 2007. Mol. Cancer Ther. 6, 450.