528240 Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets

528240
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      Overview

      Replacement Information

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      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      528240-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewNative, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds to fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.
          Catalogue Number528240
          Brand Family Calbiochem®
          SynonymsGPIIbIIIa, Fibrinogen Receptor, CD41/CD61
          References
          ReferencesSchwarz M., et al. 2004. J. Pharmacol. Exp. Therap. 308, 1002.
          Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.
          Product Information
          FormLiquid
          FormulationIn 100 mM NaCl, 20 mM Tris-HCl, 1 mM CaCl₂, 50% glycerol, 0.1% TRITON® X-100 Detergent, ≤0.1% sodium azide, pH 7.4.
          Applications
          Biological Information
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Avoid freeze/thaw cycles.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets SDS

          Title

          Safety Data Sheet (SDS) 

          Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets Certificates of Analysis

          TitleLot Number
          528240

          References

          Reference overview
          Schwarz M., et al. 2004. J. Pharmacol. Exp. Therap. 308, 1002.
          Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-January-2008 JSW
          SynonymsGPIIbIIIa, Fibrinogen Receptor, CD41/CD61
          DescriptionNative, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.
          FormLiquid
          FormulationIn 100 mM NaCl, 20 mM Tris-HCl, 1 mM CaCl₂, 50% glycerol, 0.1% TRITON® X-100 Detergent, ≤0.1% sodium azide, pH 7.4.
          Concentration Label Please refer to vial label for lot-specific concentration
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Avoid freeze/thaw cycles.
          Toxicity Standard Handling
          ReferencesSchwarz M., et al. 2004. J. Pharmacol. Exp. Therap. 308, 1002.
          Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.