506155 | Pifithrin-μ - CAS 64984-31-2 - Calbiochem

506155
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₇NO₂S 64984-31-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      506155-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.
          Catalogue Number506155
          Brand Family Calbiochem®
          SynonymsPhenylacetylenylsulfonamide, Hsp70 Inhibitor I
          References
          ReferencesLeu, J., et al. 2009. Mol. Cell 36, 15.
          Strom, E., et al. 2006. Nat. Chem. Biol. 2, 474.
          Product Information
          CAS number64984-31-2
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₈H₇NO₂S
          Chemical formulaC₈H₇NO₂S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationPifithrin-μ, CAS 64984-31-2, is a cell-permeable inhibitor of p53 interaction with Bcl-xL & Bcl-2. Inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.
          Biological Information
          Primary Targetp53 interaction with Bcl-xL and Bcl-2 proteins
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          506155

          References

          Reference overview
          Leu, J., et al. 2009. Mol. Cell 36, 15.
          Strom, E., et al. 2006. Nat. Chem. Biol. 2, 474.

          Brochure

          Title
          Biologics 33.1 ( 1.37 MB )
          p53 Pathway Poster ( 386 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-October-2009 RFH
          SynonymsPhenylacetylenylsulfonamide, Hsp70 Inhibitor I
          DescriptionA cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number64984-31-2
          Chemical formulaC₈H₇NO₂S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLeu, J., et al. 2009. Mol. Cell 36, 15.
          Strom, E., et al. 2006. Nat. Chem. Biol. 2, 474.