524390 | Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem

524390
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₄₀O₈ 37558-16-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      524390-1MG
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          Alu drum 1 mg
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          524390-5MG
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              Alu drum 5 mg
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              Description
              OverviewStrong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Promotes the expression of inducible NOS in cultured hepatocytes. Commonly used in binding studies or in applications requiring high concentrations of phorbol compounds.
              Catalogue Number524390
              Brand Family Calbiochem®
              SynonymsPDBu, PKC Activator II
              References
              ReferencesFisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
              Lee, E.J., et al. 1994. Brain Res. 665, 127.
              Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
              Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
              Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
              Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
              Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.
              Product Information
              CAS number37558-16-0
              ATP CompetitiveN
              FormClear film or white crystalline solid
              Hill FormulaC₂₈H₄₀O₈
              Chemical formulaC₂₈H₄₀O₈
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetNa+,K+- ATPase
              Purity≥99% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSEK7767000
              Safety Information
              R PhraseR: 26/27/28-36/37/38-40-41

              Very toxic by inhalation, in contact with skin and if swallowed.
              Irritating to eyes, respiratory system and skin.
              Limited evidence of a carcinogenic effect.
              Risk of serious damage to eyes.
              S PhraseS: 26-36/37/39-45

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing, gloves and eye/face protection.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Highly Toxic & Carcinogenic / Teratogenic
              Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              524390

              References

              Reference overview
              Fisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
              Lee, E.J., et al. 1994. Brain Res. 665, 127.
              Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
              Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
              Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
              Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
              Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.

              Brochure

              Title
              PKC Pathway Poster PDF ( 676 KB )
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision19-August-2008 RFH
              SynonymsPDBu, PKC Activator II
              DescriptionStrong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C (PKC). Stimulates the phosphorylation of Na+-K+ ATPase, thereby inhibiting its activity. Promotes the expression of iNOS in cultured hepatocytes. PDBu can be diluted to 30 µM in aqueous solutions, so it is commonly used in binding studies or in applications requiring high concentrations. It is easier to remove PDBu than PMA from cells in culture.
              FormClear film or white crystalline solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number37558-16-0
              RTECSEK7767000
              Chemical formulaC₂₈H₄₀O₈
              Structure formulaStructure formula
              Purity≥99% by HPLC
              SolubilityDMSO (10 mg/ml). Further dilute with aqueous buffers just prior to use.
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
              Toxicity Highly Toxic & Carcinogenic / Teratogenic
              ReferencesFisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
              Lee, E.J., et al. 1994. Brain Res. 665, 127.
              Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
              Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
              Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
              Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
              Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.