504974 | Philanthotoxin-7,4 - CAS 401601-12-5 - Calbiochem

504974
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₄₂N₄O₃•2HCl 401601-12-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04974.0001
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          Glass bottle 1 mg
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          Description
          OverviewA potent competitive antagonist highly selective for GluA1, GluA3, and GluA1/A2 subtype AMPA receptors (Ki = 0.168 and 1.6 µM for GluA1 and GluA1/A2, respectively). Negligible effect at GluA2 and GluA2/A3 subtype AMPA receptors. Used in studies of circadian rhythm, addition, and sleep.
          Catalogue Number504974
          Brand Family Calbiochem®
          Synonyms(S)-N-(1-((7-((4-aminobutyl)amino)heptyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide, Philanthotoxin-74, PhTx-74, AMPA Glutamate Antagonist, Philanthotoxin-7,4
          References
          ReferencesJackson, C., et al. 2011. J. Neurosci. 31, 7511.
          Lante, F., et al. 2011. J. Neurosci. 31, 3953.
          Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
          Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
          Kromann, H. et al. 2002. J. Med. Chem. 45, 5745.
          Product Information
          CAS number401601-12-5
          FormLyophilized powder
          FormulationSupplied as a dihydrochloride salt.
          Hill FormulaC₂₄H₄₂N₄O₃•2HCl
          Chemical formulaC₂₄H₄₂N₄O₃•2HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAMPA
          Primary Target K<sub>i</sub>0.168 and 1.6 →M for GluA1 and GluA1/A2, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Jackson, C., et al. 2011. J. Neurosci. 31, 7511.
          Lante, F., et al. 2011. J. Neurosci. 31, 3953.
          Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
          Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
          Kromann, H. et al. 2002. J. Med. Chem. 45, 5745.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-August-2013 JSW
          Synonyms(S)-N-(1-((7-((4-aminobutyl)amino)heptyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide, Philanthotoxin-74, PhTx-74, AMPA Glutamate Antagonist, Philanthotoxin-7,4
          DescriptionA potent competitive antagonist highly selective for GluA1, GluA3, and GluA1/A2 subtype AMPA receptors (Ki = 0.168 and 1.6 µM for GluA1 and GluA1/A2, respectively). Negligible effect at GluA2 and GluA2/A3 subtype AMPA receptors. Used in studies of circadian rhythm, addition, and sleep.
          FormLyophilized powder
          FormulationSupplied as a dihydrochloride salt.
          CAS number401601-12-5
          Chemical formulaC₂₄H₄₂N₄O₃•2HCl
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesJackson, C., et al. 2011. J. Neurosci. 31, 7511.
          Lante, F., et al. 2011. J. Neurosci. 31, 3953.
          Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
          Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
          Kromann, H. et al. 2002. J. Med. Chem. 45, 5745.