521000 Phenylarsine Oxide - CAS 637-03-6 - Calbiochem

521000
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆H₅AsO 637-03-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      521000-250MG
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          Alu drum 250 mg
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          Description
          OverviewA membrane-permeable protein tyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates p56lck protein tyrosine kinase. Blocks TNF-α-dependent activation of NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases as well as endogenous caspases that are active in extracts of pre-apoptotic chicken DU249 cells (S/M extracts).
          Catalogue Number521000
          Brand Family Calbiochem®
          SynonymsPAO, Oxophenylarsine, PTP Inhibitor IX, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II
          References
          ReferencesTakahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
          Carey, J.O., et al. 1995. Diabetes 44, 1995.
          Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067.
          Oetken, C., et al. 1995. Mol. Immunol. 31, 1295.
          Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.
          Product Information
          CAS number637-03-6
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₆H₅AsO
          Chemical formulaC₆H₅AsO
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetProtein tyrosine phosphatase
          Primary Target IC<sub>50</sub>18 µM against protein tyrosine phosphatase
          Purity≥96% by titration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSCH8100000
          Safety Information
          R PhraseR: 26/27/28-34-40

          Very toxic by inhalation, in contact with skin and if swallowed.
          Causes burns.
          Limited evidence of a carcinogenic effect.
          S PhraseS: 26-27-36/37/39-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Take off immediately all contaminated clothing.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          521000

          References

          Reference overview
          Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
          Carey, J.O., et al. 1995. Diabetes 44, 1995.
          Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067.
          Oetken, C., et al. 1995. Mol. Immunol. 31, 1295.
          Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.

          Brochure

          Title
          Protease and Phosphatase Inhibitor Cocktails Brochure
          Protein Phosphatases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-September-2008 JSW
          SynonymsPAO, Oxophenylarsine, PTP Inhibitor IX, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II
          DescriptionA membrane-permeable phosphotyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates P56lck protein tyrosine kinase. Blocks TNFα-dependent activation of the NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases, as well as endogenous chicken caspases that are active in extracts of preapoptotic chicken DU249 cells (S/M extracts). At 100 µM, it also blocks the morphological changes of nuclear apoptosis in vitro and internucleosomal DNA fragmentation in S/M extracts without interfering with PARP or lamin A cleavage. Also known to cause complete and reversible inhibition of NADPH oxidase in human neutrophils.
          FormWhite solid
          CAS number637-03-6
          RTECSCH8100000
          Chemical formulaC₆H₅AsO
          Structure formulaStructure formula
          Purity≥96% by titration
          SolubilityCHCl₃ (100 mg/ml) or DMSO (50 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 6949
          ReferencesTakahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
          Carey, J.O., et al. 1995. Diabetes 44, 1995.
          Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067.
          Oetken, C., et al. 1995. Mol. Immunol. 31, 1295.
          Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.