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Description
Overview
A membrane-permeable protein tyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates p56lck protein tyrosine kinase. Blocks TNF-α-dependent activation of NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases as well as endogenous caspases that are active in extracts of pre-apoptotic chicken DU249 cells (S/M extracts).
Catalogue Number
521000
Brand Family
Calbiochem®
Synonyms
PAO, Oxophenylarsine, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II, PTP Inhibitor IX
References
References
Takahashi, A., et al. 1997. Exp. Cell Res.231, 123. Carey, J.O., et al. 1995. Diabetes44, 1995. Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem.270, 2067. Oetken, C., et al. 1995. Mol. Immunol.31, 1295. Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem.270, 10631.
Product Information
CAS number
637-03-6
ATP Competitive
N
Form
White solid
Hill Formula
C₆H₅AsO
Chemical formula
C₆H₅AsO
Reversible
N
Structure formula Image
Applications
Biological Information
Primary Target
Protein tyrosine phosphatase
Primary Target IC<sub>50</sub>
18 µM against protein tyrosine phosphatase
Purity
≥96% by titration
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
CH8100000
Safety Information
R Phrase
R: 26/27/28-34-40
Very toxic by inhalation, in contact with skin and if swallowed. Causes burns. Limited evidence of a carcinogenic effect.
S Phrase
S: 26-27-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Take off immediately all contaminated clothing. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+15°C to +30°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Documentation
Phenylarsine Oxide - CAS 637-03-6 - Calbiochem SDS
Phenylarsine Oxide - CAS 637-03-6 - Calbiochem Certificates of Analysis
Title
Lot Number
521000
References
Reference overview
Takahashi, A., et al. 1997. Exp. Cell Res.231, 123. Carey, J.O., et al. 1995. Diabetes44, 1995. Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem.270, 2067. Oetken, C., et al. 1995. Mol. Immunol.31, 1295. Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem.270, 10631.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
25-September-2008 JSW
Synonyms
PAO, Oxophenylarsine, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II, PTP Inhibitor IX
Description
A membrane-permeable phosphotyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates P56lck protein tyrosine kinase. Blocks TNFα-dependent activation of the NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases, as well as endogenous chicken caspases that are active in extracts of preapoptotic chicken DU249 cells (S/M extracts). At 100 µM, it also blocks the morphological changes of nuclear apoptosis in vitro and internucleosomal DNA fragmentation in S/M extracts without interfering with PARP or lamin A cleavage. Also known to cause complete and reversible inhibition of NADPH oxidase in human neutrophils.
Form
White solid
CAS number
637-03-6
RTECS
CH8100000
Chemical formula
C₆H₅AsO
Structure formula
Purity
≥96% by titration
Solubility
CHCl₃ (100 mg/ml) or DMSO (50 mg/ml)
Storage
+15°C to +30°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Highly Toxic & Carcinogenic / Teratogenic
Merck USA index
14, 6949
References
Takahashi, A., et al. 1997. Exp. Cell Res.231, 123. Carey, J.O., et al. 1995. Diabetes44, 1995. Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem.270, 2067. Oetken, C., et al. 1995. Mol. Immunol.31, 1295. Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem.270, 10631.
