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516854 | Pertussis Toxin, A Protomer, Bordetella pertussis - Calbiochem

516854
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      516854-10UG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
        Remaining : Will advise
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          Alu drum 10 μg
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          Description
          OverviewEnzymatic component of the holotoxin. Has both NAD-glycohydrolase and ADP-ribosyltransferase activities. Inhibits neutrophil-mediated inflammation in vivo via its ADP-ribosylation activity. Unable to penetrate cells in the absence of the B oligomer.
          Catalogue Number516854
          Brand Family Calbiochem®
          References
          ReferencesBrito, G.A., et al. 1997. Infect. Immun. 65, 1114.
          Gill, D.M., and Coburn, J., 1988. Biochim. Biophys. Acta 954, 65.
          Kaslow, H.R., and Lesikar, D.D., 1987. Biochemistry 26, 4397.
          Burns, D.L., and Manclark, C.R., 1986. J. Biol. Chem. 261, 4324.
          Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
          Tamura, M., et al. 1982. Biochemistry 21, 5516.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationLyophilized from 10 mM Tris, 100 µM EDTA, 0.04% CHAPS, pH 8.0.
          ReversibleN
          Applications
          Biological Information
          Primary TargetHas both NAD-glycohydrolase and ADP-ribosyltransferase activities
          PuritySingle major band by SDS-PAGE
          Physicochemical Information
          Cell permeableN
          Contaminants≤0.1% holotoxin by CHO cell assay
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 23/24/25

          Toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions, prepared from high ionic strength buffers, are stable for up to 3 months at 4°C.
          Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          516854

          References

          Reference overview
          Brito, G.A., et al. 1997. Infect. Immun. 65, 1114.
          Gill, D.M., and Coburn, J., 1988. Biochim. Biophys. Acta 954, 65.
          Kaslow, H.R., and Lesikar, D.D., 1987. Biochemistry 26, 4397.
          Burns, D.L., and Manclark, C.R., 1986. J. Biol. Chem. 261, 4324.
          Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
          Tamura, M., et al. 1982. Biochemistry 21, 5516.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-August-2008 RFH
          DescriptionEnzymatic component of the holotoxin. Has NAD-glycohydrolase activities. Unable to penetrate cells in the absence of the B oligomer.
          FormLyophilized
          FormulationLyophilized from 10 mM Tris, 100 µM EDTA, 0.04% CHAPS, pH 8.0.
          PuritySingle major band by SDS-PAGE
          Contaminants≤0.1% holotoxin by CHO cell assay
          SolubilityReconstitute with 500 µl sterile dH₂O or high ionic buffer.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions, prepared from high ionic strength buffers, are stable for up to 3 months at 4°C.
          Toxicity Toxic
          ReferencesBrito, G.A., et al. 1997. Infect. Immun. 65, 1114.
          Gill, D.M., and Coburn, J., 1988. Biochim. Biophys. Acta 954, 65.
          Kaslow, H.R., and Lesikar, D.D., 1987. Biochemistry 26, 4397.
          Burns, D.L., and Manclark, C.R., 1986. J. Biol. Chem. 261, 4324.
          Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
          Tamura, M., et al. 1982. Biochemistry 21, 5516.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Toxins