516620 Peroxynitrite - Calbiochem

516620
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      516620-1SET
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          Alu drum 1 set
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          Description
          OverviewSynthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO) is a cell-permeable strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. Has been implicated in a variety of pathophysiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock.
          Note: 1 set = 2 x 1 ml.
          Catalogue Number516620
          Brand Family Calbiochem®
          References
          ReferencesMarla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
          Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
          Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
          Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
          Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.
          Product Information
          ATP CompetitiveN
          FormYellow liquid
          FormulationSupplied in 4.7% NaOH at 160-200 mM.
          ReversibleN
          Applications
          ApplicationPeroxynitrite, CAS 14042-01-4, is a cell-permeable, short-lived, strong biological oxidant agent that reacts with and can damage DNA, membrane phospholipids, sulfhydryl groups, and tyrosine.
          Biological Information
          Primary TargetOxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 8-20/22-34

          Contact with combustible material may cause fire.
          Harmful by inhalation and if swallowed.
          Causes burns.
          S PhraseS: 3-28-36/37/39-45

          Keep in a cool place.

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Oxidizer
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage ≤ -70°C
          Protect from Light Protect from light
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsProtect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          516620

          References

          Reference overview
          Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
          Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
          Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
          Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
          Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Pathways and Biomarkers of Oxidative Stress (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-November-2007 JSW
          DescriptionSynthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO–) is a strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. It has been implicated in a variety of patho-physiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock. This product decomposes or isomerizes at pH 8 or less; the half-life at pH 7.5 is ~1.5 s. ε302 nm = 1670M-1cm-1 in 0.1 MNaOH.
          FormYellow liquid
          FormulationSupplied in 4.7% NaOH at 160-200 mM.
          Intert gas (Yes/No) Packaged under inert gas
          SolubilityPeroxynitrite is soluble in aqueous buffers that have been pre-purged with an inert gas and pre-cooled to 4°C.
          Storage ≤ -70°C
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsProtect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C.
          Toxicity Oxidizer
          ReferencesMarla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
          Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
          Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
          Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
          Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.