516483 Pepstatin A, Penetratin - Calbiochem

516483
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₃₈H₂₂₉N₃₉O₂₈S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      516483-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells.
          Catalogue Number516483
          Brand Family Calbiochem®
          SynonymsPepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈
          References
          ReferencesZaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.
          Product Information
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₃₈H₂₂₉N₃₉O₂₈S
          Chemical formulaC₁₃₈H₂₂₉N₃₉O₂₈S
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Peptide SequencePepA-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-CO₂H
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          516483

          References

          Reference overview
          Zaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2009 RFH
          SynonymsPepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈
          DescriptionA Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₃₈H₂₂₉N₃₉O₂₈S
          Peptide SequencePepA-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-CO₂H
          Purity≥97% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesZaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.