516485 Pepstatin A Methyl Ester - Calbiochem

516485
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₅H₆₅N₅O₉

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      516485-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516481) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (Kis = 150 nM, Kii = 320 nM in solubilized human γ-secretase at 20°C; Kis is the inhibition constant for inhibitor binding to the free enzyme and Kii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex). Sta = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid.
          Catalogue Number516485
          Brand Family Calbiochem®
          SynonymsIsovaleryl-V V-Sta-A-Sta-OCH₃, PME
          References
          ReferencesTian, G., et al. 2002. J. Biol. Chem. 277, 31499.
          Zhang, L., et al. 2001. Biochemistry 40, 5049.
          Murphy, M.P., et al. 1999. J. Biol. Chem. 274, 11914.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          Hill FormulaC₃₅H₆₅N₅O₉
          Chemical formulaC₃₅H₆₅N₅O₉
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetγ-secretase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          516485

          References

          Reference overview
          Tian, G., et al. 2002. J. Biol. Chem. 277, 31499.
          Zhang, L., et al. 2001. Biochemistry 40, 5049.
          Murphy, M.P., et al. 1999. J. Biol. Chem. 274, 11914.

          Brochure

          Title
          Alzheimer's Disease Brochure & Technical Guide
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-August-2008 RFH
          SynonymsIsovaleryl-V V-Sta-A-Sta-OCH₃, PME
          DescriptionA cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516482) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (Kis = 15 nM and Kii = 32 nM in solubilized human γ-secretase; Kis is the inhibition constant for inhibitor binding to the free enzyme and Kii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex).
          FormLyophilized
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₅H₆₅N₅O₉
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesTian, G., et al. 2002. J. Biol. Chem. 277, 31499.
          Zhang, L., et al. 2001. Biochemistry 40, 5049.
          Murphy, M.P., et al. 1999. J. Biol. Chem. 274, 11914.