A part of MilliporeSigma

Pellicon® XL 50 Microfiltration Cassettes

The Pellicon® XL 50 cassette couples Millipore's superior microfiltration membranes with the first truly linearly scalable TFF device for processing small volumes.

Overview

Specifications

Ordering Information

Hydrophilic PVDF Clear Sorting & Filtering
Catalog Numbericon Filter Codeicon Pore Sizeicon
PXDVPPC50DVPP 0.65 µm Show Pricing & Availability
PXGVPPC50GVPP 0.22 µm Show Pricing & Availability
PXHVMPC50HVMP 0.45 µm Show Pricing & Availability
PXVVPPC50VVPP 0.1 µm Show Pricing & Availability

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Accessories Clear Sorting & Filtering
Catalog Numbericon Descriptionicon
XX42RES05Reservoir, 100 mL, for LabScale Show Pricing & Availability
XXPXLFTKTFittings Adapters and Tubing Show Pricing & Availability
XXPXLGAGEGauge 0-60 psi and Connection Fittings Show Pricing & Availability
XXPXLSTNDStand for Pellicon® XL Show Pricing & Availability

Each Pellicon XL device is packaged one per box

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    Documentation

    References

    Reference overview
    Scaling Up with Tangenital Flow Filtration
    Campbell, Melissa; Coons, Elizabeth
    GEN; v. 21, no. 16; Sept. 15, 2001, p. 60 2001

    Evaluation of Microporous Tangential-Flow Filtration in the Production of Diphtheria and Pertussis Vaccines
    Rao, Y. Udaya Bhaskara, M.S. Mahadevan, and Stephen L. Michaels; Pharmaceutical Technology
    Pharmaceutical Technology 1992

    Validation of Tangential Flow Filtration (TFF) Systems
    Michaels, Stephen L.
    Journal of Parenteral Science and Technology (Sept/Oct 1991). 1991

    FAQ

    QuestionAnswer
    What is Normalized Water Permeability? NWP is a measure of the ability of pure water to pass through the filter membrane. NWP is a property of the TFF system and is contributed to by the membrane as well as the feed and permeate flow paths in the filter.
    How is NWP measured? NWP is measured by filtering pure water throught he system at controlled cross flow, Trans Membrane Pressure and temperature. The filtrate flow rate is measured. The flow rate is normalized to the membrane area, TMP and temperature.

    Please refer to the operator's manual or contact Techical Service for further questions regarding the calculation of NWP.
    How does NWP aid in effective cleaning procedure development? Fouling and polarization leave residues on the membrane that can reduce filter permeability. Effective cleaning removes these residues, restoring the permeability of the membrane. Ideally, NWP after cleaning should equal NWP before use although there can be variation up to +/-15% due to membrane compaction under pressure and measurement error.

    NWP validates the ability of cleaning to restore filtration rate of a system.
    What is the part number for the Gauge Kit that is used with the Pellicon XL? Gauge Kit for Pellicon XL Device (0-60 psi):
    Part number XXPXLGAGE, 1 per kit. Includes an inlet pressure gauge and t-fitting. This gauge is recommended when the Pellicon is used in the absence of a Labscale TFF system in order to ensure that the pressure on the tubing is known and not allowed to exceed it's recommended maximum.
    Are there any microporous offerings in the tangential flow filtration line of products? While the Prep/Scale and Pellicon XL are not available in a microporous format, the Pellicon II Mini and Pellicon II systems are. The microporous membranes are made of Millipore's Durapore membrane, low protein binding PVDF, and are available in 0.1um, 0.22um, 0.45um, and 0.65um.
    What is the sample volume range for the Pellicon II Mini system? The Pellicon II Mini system is capable of volumes in the approximate range of 1- 50 L concentrating down to 100 mL. More or less volume can be processed depending on the individual needs of the operation, ie. process time, sensitivity of product, etc.
    Is there a prefiltration requirement for use with the Pellicon system? Yes, the Pellicon system requires a 100um prefiltration. Depending on the process volume, Millipore offers an array of prefiltration modules. Contact Technical Services for help in choosing a module.

    User Guides

    Title
    Pellicon® XL Device Operating Instructions

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    Categories

    Biopharmaceutical Manufacturing > Downstream Processing > Ultrafiltration