512731 | Paromomycin Sulfate - CAS 1263-89-4 - Calbiochem

512731
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₄₅N₅O₁₄ · H₂SO₄ 1263-89-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      512731-5GM
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          Glass bottle 5 gm
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          Description
          OverviewAn aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity. Recent NMR evidence indicates that paromomycin binding to the A-site of 16S rRNA induces a local conformational change, suggesting a mechanism for aminoglycoside action on protein translation. Also exhibits anti-protozoal properties.
          Potency: ≥675 µg/mg.
          Catalogue Number512731
          Brand Family Calbiochem®
          SynonymsNeomycin E
          References
          ReferencesVanLoock, M.S., et al. 1999. J. Mol. Biol. 285, 2069.
          Blanchard, S.C., et al. 1998. Biochemistry 37, 7716.
          Fourmy, D., et al. 1998. J. Mol. Biol. 277, 333.
          Product Information
          CAS number1263-89-4
          FormOff-white solid
          Hill FormulaC₂₃H₄₅N₅O₁₄ · H₂SO₄
          Chemical formulaC₂₃H₄₅N₅O₁₄ · H₂SO₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSWK2320000
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-24/25-36/37/39-45

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          512731

          References

          Reference overview
          VanLoock, M.S., et al. 1999. J. Mol. Biol. 285, 2069.
          Blanchard, S.C., et al. 1998. Biochemistry 37, 7716.
          Fourmy, D., et al. 1998. J. Mol. Biol. 277, 333.

          Brochure

          Title
          Antibiotics Profiler
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-October-2010 JSW
          SynonymsNeomycin E
          DescriptionAn aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity. Recent NMR evidence indicates paromomycin binding to the A-site of 16S rRNA induces a local conformational change that suggests a mechanism for aminoglycoside action on protein translation.
          FormOff-white solid
          CAS number1263-89-4
          RTECSWK2320000
          Chemical formulaC₂₃H₄₅N₅O₁₄ · H₂SO₄
          Structure formulaStructure formula
          SolubilityH₂O
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Toxicity Harmful
          Merck USA index14, 7041
          ReferencesVanLoock, M.S., et al. 1999. J. Mol. Biol. 285, 2069.
          Blanchard, S.C., et al. 1998. Biochemistry 37, 7716.
          Fourmy, D., et al. 1998. J. Mol. Biol. 277, 333.