537983 Pantothenate Kinase Inhibitor - Calbiochem

537983
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      Overview

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      5.37983.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable pyridopyrazolopyrimidine based compound that acts as a potent and reversible inhibitor of pantothenate kinase (IC50 = 70, 92 and 25 nM for PanK1β, PanK2 and PanK3, respectively; radiochemical assay, 2.5 mM [ATP]). Binds to ATP-PanK complex (apparent binding constant ~300 nM for ATP-PanK3) and exhibits mixed-type inhibition with respect to ATP and pantothenate. Shown to dose-dependently decrease [3H]pantothenate incorporation into coenzyme A (apparent IC50 = 900 nM in C3A cells) with negligible off-target toxicity (IC50 > 56 µM in Hep-G2 cells).

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number537983
          Brand Family Calbiochem®
          Synonyms3-(2,4-Dimethylpyrido-[2ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-(methylthio)phenyl)propanamide, PanK Inhibitor
          DescriptionPantothenate Kinase Inhibitor
          References
          ReferencesSharma, L.K., et al. 2015. J. Med. Chem. 58, 1563.
          Product Information
          FormOrange solid
          Hill FormulaC₂₁H₂₁N₅O
          Chemical formulaC₂₁H₂₁N₅O
          ReversibleY
          Applications
          Biological Information
          Primary Targetpantothenate kinase
          Primary Target IC<sub>50</sub>70, 92 and 25 nM for PanK1&beta
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Pantothenate Kinase Inhibitor - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Sharma, L.K., et al. 2015. J. Med. Chem. 58, 1563.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-September-2016 JSW
          Synonyms3-(2,4-Dimethylpyrido-[2ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-(methylthio)phenyl)propanamide, PanK Inhibitor
          DescriptionA cell-permeable pyridopyrazolopyrimidine based compound that acts as a potent and reversible inhibitor of pantothenate kinase (IC50 = 70, 92 and 25 nM for PanK1β, PanK2 and PanK3, respectively; radiochemical assay, 2.5 mM [ATP]). Binds to ATP-PanK complex (apparent binding constant ~300 nM for ATP-PanK3) and exhibits mixed-type inhibition with respect to ATP and pantothenate. Shown to dose-dependently decrease [3H]pantothenate incorporation into coenzyme A (apparent IC50 = 900 nM in C3A cells) with negligible off-target toxicity (IC50 > 56 µM in Hep-G2 cells).
          FormOrange solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₁H₂₁N₅O
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSharma, L.K., et al. 2015. J. Med. Chem. 58, 1563.