506600 Pamidronate, Disodium Salt - CAS 109552-15-0 - Calbiochem

506600
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃H₉NO₇P₂·2Na·5H₂O 109552-15-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      506600-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget’s disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water.
          Catalogue Number506600
          Brand Family Calbiochem®
          Synonyms3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate
          References
          ReferencesFromigue, O., et al. 2000. J. Bone Miner. Res. 15, 2211.
          Fitton, A., and McTravish, D. 1991. Drugs 41, 289.
          Product Information
          CAS number109552-15-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃H₉NO₇P₂·2Na·5H₂O
          Chemical formulaC₃H₉NO₇P₂·2Na·5H₂O
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetInhibitor of bone resorption
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSSZ6522666
          Safety Information
          R PhraseR: 20/21/22-61

          Harmful by inhalation, in contact with skin and if swallowed.
          May cause harm to the unborn child.
          S PhraseS: 36-45

          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          506600

          References

          Reference overview
          Fromigue, O., et al. 2000. J. Bone Miner. Res. 15, 2211.
          Fitton, A., and McTravish, D. 1991. Drugs 41, 289.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-May-2008 RFH
          Synonyms3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate
          DescriptionA calcium metabolism regulator. A potent and specific inhibitor of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralization. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget's disease, hypercalcemia of malignancy, osteolytic bone metastasis, and steroid-induced cell death in vitro. Provided in a hydrated form containing five molecules of water.
          FormWhite solid
          CAS number109552-15-0
          RTECSSZ6522666
          Chemical formulaC₃H₉NO₇P₂·2Na·5H₂O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (10 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 7003
          ReferencesFromigue, O., et al. 2000. J. Bone Miner. Res. 15, 2211.
          Fitton, A., and McTravish, D. 1991. Drugs 41, 289.