580556 Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem

580556
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₇H₅₁NO₁₄ 33069-62-4

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      580556-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA semi-synthetic form of Paclitaxel (Cat. No. 580555) having no contamination by natural taxanes. Also has reduced levels of epimerization products as contaminants.
          Catalogue Number580556
          Brand Family Calbiochem®
          References
          ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
          Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
          Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
          Hornback, N.B., et al. 1994. In Vivo 8, 819.
          Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
          Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
          Ding, A.H., et al. 1990. Science 248, 370.
          Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
          Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
          Product Information
          CAS number33069-62-4
          ATP CompetitiveN
          FormCrystalline solid
          Hill FormulaC₄₇H₅₁NO₁₄
          Chemical formulaC₄₇H₅₁NO₁₄
          ReversibleN
          Applications
          Biological Information
          Primary TargetPromotes assembly of microtubules and inhibits tubulin disassembly.
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDA8340700
          Safety Information
          R PhraseR: 37/38-41-46-60

          Irritating to respiratory system and skin.
          Risk of serious damage to eyes.
          May cause heritable genetic damage.
          May impair fertility.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          580556

          References

          Reference overview
          Derry, W.B., et al. 1995. Biochemistry 34, 2203.
          Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
          Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
          Hornback, N.B., et al. 1994. In Vivo 8, 819.
          Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
          Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
          Ding, A.H., et al. 1990. Science 248, 370.
          Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
          Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-May-2011 JSW
          DescriptionA semi-synthetically derived form of Paclitaxel (TAXOL®, Cat. No. 580555) having no contamination of natural taxanes. Also has less epimerization products as contaminants. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
          FormCrystalline solid
          CAS number33069-62-4
          RTECSDA8340700
          Chemical formulaC₄₇H₅₁NO₁₄
          Purity≥97% by HPLC
          SolubilityDMSO or methanol
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 6982
          ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
          Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
          Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
          Hornback, N.B., et al. 1994. In Vivo 8, 819.
          Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
          Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
          Ding, A.H., et al. 1990. Science 248, 370.
          Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
          Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

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          Catalog Number Description  
          580555 Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem Show Pricing & Availability

          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Extracellular Matrix, Adhesion and Cytoskeletal Research Tools