520219 PPACK II, Trifluoroacetate Salt - CAS 74392-49-7 - Calbiochem

520219
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₃₃ClN₆O₃ . 2CF₃COOH 74392-49-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      520219-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewPotent and specific irreversible inhibitor of plasma and glandular kallikreins. Also available as a 10 mM solution in H2O (Cat. No. 508573).
          Catalogue Number520219
          Brand Family Calbiochem®
          References
          ReferencesByrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.
          Scicli, G., et al. 1989. Adv. Exp. Med. Biol. 247B, 217.
          Gibson, T.R., et al. 1987. Endocrinology 120, 764.
          Kettner, G., and Shaw, E. 1981. Methods Enzymol. 80, 826.
          Product Information
          CAS number74392-49-7
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₅H₃₃ClN₆O₃ . 2CF₃COOH
          Chemical formulaC₂₅H₃₃ClN₆O₃ . 2CF₃COOH
          ReversibleN
          Applications
          ApplicationPPACK II, Trifluoroacetate Salt, CAS 74392-49-7, is a potent, specific, and irreversible inhibitor of plasma and glandular kallikreins.
          Biological Information
          Primary TargetPlasma and glandular kallikreins
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-D-Phe-Phe-Arg-chloromethylketone, 2TFA
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          520219

          References

          Reference overview
          Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.
          Scicli, G., et al. 1989. Adv. Exp. Med. Biol. 247B, 217.
          Gibson, T.R., et al. 1987. Endocrinology 120, 764.
          Kettner, G., and Shaw, E. 1981. Methods Enzymol. 80, 826.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-October-2013 JSW
          DescriptionPotent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme.
          FormOff-white solid
          CAS number74392-49-7
          Chemical formulaC₂₅H₃₃ClN₆O₃ . 2CF₃COOH
          Peptide SequenceH-D-Phe-Phe-Arg-chloromethylketone, 2TFA
          Purity≥95% by HPLC
          SolubilityH₂O (100 mg/ml)
          Storage +2°C to +8°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesByrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.
          Scicli, G., et al. 1989. Adv. Exp. Med. Biol. 247B, 217.
          Gibson, T.R., et al. 1987. Endocrinology 120, 764.
          Kettner, G., and Shaw, E. 1981. Methods Enzymol. 80, 826.