505278 | PNU 282987 - CAS 123464-89-1 - Calbiochem

505278
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₇ClN₂O•HCl 123464-89-1

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05278.0001
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          Glass bottle 10 mg
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          Description
          OverviewA potent agonist highly selective for α7 nAChRs (Ki = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.
          Catalogue Number505278
          Brand Family Calbiochem®
          SynonymsN-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride, α7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987, PNU-282987
          References
          ReferencesHajós, M., et al., 2010, Curr. Pharm. Des. 16, 538.
          Bodnar, L., et al., 2005. J. Med. Chem. 48, 905.
          Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther. 312, 1213.
          Product Information
          CAS number123464-89-1
          FormOff-white solid
          Hill FormulaC₁₄H₁₇ClN₂O•HCl
          Chemical formulaC₁₄H₁₇ClN₂O•HCl
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetα7 nAChRs
          Primary Target K<sub>i</sub>26 nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Hajós, M., et al., 2010, Curr. Pharm. Des. 16, 538.
          Bodnar, L., et al., 2005. J. Med. Chem. 48, 905.
          Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther. 312, 1213.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          SynonymsN-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride, α7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987, PNU-282987
          DescriptionA potent agonist highly selective for α7 nAChRs (Ki = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.
          FormOff-white solid
          CAS number123464-89-1
          Chemical formulaC₁₄H₁₇ClN₂O•HCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityH₂O (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHajós, M., et al., 2010, Curr. Pharm. Des. 16, 538.
          Bodnar, L., et al., 2005. J. Med. Chem. 48, 905.
          Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther. 312, 1213.