528245 PLD Inhibitor, FIPI - Calbiochem

528245
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₃H₂₄FN₅O₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      528245-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable, PLD1/2 inhibitor (IC50 = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50 = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.
          Catalogue Number528245
          Brand Family Calbiochem®
          SynonymsCompound 4k, PLD Inhibitor I
          References
          ReferencesSu, W., et al. 2009. Mol Pharmacol 75, 437.
          Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.
          Product Information
          FormOff-white powder
          Hill FormulaC₂₃H₂₄FN₅O₂
          Chemical formulaC₂₃H₂₄FN₅O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PLD Inhibitor, FIPI - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          PLD Inhibitor, FIPI - Calbiochem Certificates of Analysis

          TitleLot Number
          528245

          References

          Reference overview
          Su, W., et al. 2009. Mol Pharmacol 75, 437.
          Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-August-2012 JSW
          SynonymsCompound 4k, PLD Inhibitor I
          DescriptionA cell-permeable, PLD1/2 inhibitor (IC50 = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50 = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₃H₂₄FN₅O₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSu, W., et al. 2009. Mol Pharmacol 75, 437.
          Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.