539610 PKCζ/ι Pseudosubstrate Inhibitor - Calbiochem

539610
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₇₆H₁₂₈N₃₀O₁₆

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      539610-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewA selective, reversible, and substrate competitive inhibitor of protein kinase Cζ and protein kinase Cι (PKCζ/ι) isozymes.
          Catalogue Number539610
          Brand Family Calbiochem®
          SynonymsSIYRRGARRWRKL, Protein Kinase Cζ/ι Pseudosubstrate Inhibitor
          References
          ReferencesSajan, M.P., et al. 1999. J. Biol. Chem. 274, 30495.
          Laudanna, C., et al. 1998. J. Biol. Chem. 273, 30306.
          Standaert, M.L., et al. 1997. J. Biol. Chem. 272, 30075.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₇₆H₁₂₈N₃₀O₁₆
          Chemical formulaC₇₆H₁₂₈N₃₀O₁₆
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Primary TargetPKCζ
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PKCζ/ι Pseudosubstrate Inhibitor - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          PKCζ/ι Pseudosubstrate Inhibitor - Calbiochem Certificates of Analysis

          TitleLot Number
          539610

          References

          Reference overview
          Sajan, M.P., et al. 1999. J. Biol. Chem. 274, 30495.
          Laudanna, C., et al. 1998. J. Biol. Chem. 273, 30306.
          Standaert, M.L., et al. 1997. J. Biol. Chem. 272, 30075.

          Brochure

          Title
          PKC Pathway Poster PDF ( 676 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-January-2010 RFH
          SynonymsSIYRRGARRWRKL, Protein Kinase Cζ/ι Pseudosubstrate Inhibitor
          DescriptionNon-cell-permeable protein kinase Cζ and protein kinase Cι pseudosubstrate sequence peptide that can be used as a selective, reversible, and substrate competitive inhibitor PKCζ/ι in in vitro kinase assays.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Recommended reaction conditions
          PKCζ or PKCι -containing sample is incubated at 30-37°C, with or without 400 µM PKCζ/ι pseudosubstrate inhibitor, in 50 mM Tris-HCl buffer (pH 7.5) containing 5 mM MgCl2, 100 µM Na3VO4, 100 µM Na4P2O7, 1 mM NaF, 100 µM PMSF, 50 µM ATP, 5 µCi [γ-32P]ATP, 4 µg phosphatidylserine, and 40 µM PKCζ/ι substrate (Cat. No. 539667).
          Chemical formulaC₇₆H₁₂₈N₃₀O₁₆
          Peptide SequenceH-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH
          Purity≥95% by HPLC
          SolubilityGlacial acetic acid (2 mg/ml) or H₂O (2 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSajan, M.P., et al. 1999. J. Biol. Chem. 274, 30495.
          Laudanna, C., et al. 1998. J. Biol. Chem. 273, 30306.
          Standaert, M.L., et al. 1997. J. Biol. Chem. 272, 30075.