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12-121 | PKC Inhibitor Peptide

1 mg  
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      Replacement Information
      Catalogue Number12-121
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPKC Inhibitor Peptide
      Product Information
      PresentationLyophilized powder
      ApplicationThe PKC Inhibitor Peptide controls the biological activity of PKC. This small molecule/inhibitor is primarily used for Neuroscience applications.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
      Gene Symbol
      • PRKCA
      • PKC-A
      • PKCA
      • MGC129901
      • AAG6
      • MGC129900
      • PRKACA
      • PKC-alpha
      Protein TargetPKC
      Target Sub-FamilyAGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17252 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
      COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
      SIZE: 672 amino acids; 76764 Da
      SUBUNIT: Interacts with CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.
      SIMILARITY: SwissProt: P17252 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by inhibition of Protein Kinase C
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -20°C
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information


      Certificates of Analysis

      TitleLot Number
      PKC Inhibitor Peptide - 2120114 2120114
      PKC Inhibitor Peptide - 16636 16636
      PKC Inhibitor Peptide - 17650 17650
      PKC Inhibitor Peptide - 19654 19654
      PKC Inhibitor Peptide - 2262627 2262627
      PKC Inhibitor Peptide - 22831 22831
      PKC Inhibitor Peptide - 2341059 2341059
      PKC Inhibitor Peptide - 24984 24984
      PKC Inhibitor Peptide - 32158 32158
      PKC Inhibitor Peptide - DAM1462570 DAM1462570
      PKC Inhibitor Peptide -2521308 2521308


      Reference overviewApplicationPub Med ID
      Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation
      Orr, A. W., et al
      J Biol Chem, 277:20453-60 (2002) 2002

      Kinase Assay11923291 11923291
      Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor
      McGraw, D. W. and Liggett, S. B.
      J Biol Chem, 272:7338-44 (1997) 1997

      Kinase Assay9054432 9054432
      Protein kinase C-mediated interphase lamin B phosphorylation and solubilization
      Collas, P., et al
      J Biol Chem, 272:21274-80 (1997) 1997

      Kinase Assay9261138 9261138
      Protein phosphorylation and taurine biosynthesis in vivo and in vitro
      Tang, X. W., et al
      J Neurosci, 17:6947-51 (1997) 1997

      Kinase Assay9278530 9278530
      Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites
      Pillay, T. S., et al
      J Clin Invest, 97:613-20 (1996) 1996

      8609215 8609215
      Brain L-glutamate decarboxylase. Inhibition by phosphorylation and activation by dephosphorylation
      Bao, J., et al
      J Biol Chem, 270:6464-7 (1995) 1995

      Kinase Assay7896780 7896780
      Specificities of autoinhibitory domain peptides for four protein kinases. Implications for intact cell studies of protein kinase function.
      Smith, M K, et al.
      J. Biol. Chem., 265: 1837-40 (1990) 1990

      Show Abstract
      2153665 2153665
      Protein kinase C pseudosubstrate prototope: structure-function relationships.
      House, C and Kemp, B E
      Cell. Signal., 2: 187-90 (1990) 1990

      Show Abstract
      2400634 2400634

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      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates