526559 PI3Kδ Inhibitor, SW30 - Calbiochem

526559
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₅H₂₁N₇O₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      526559-5MG
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      Stocked 
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          Glass bottle 5 mg
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          Description
          OverviewA cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kδ (IC50 = 7 nM, 1300 nM, 85000 nM, and 740 nM for PI 3-Kδ PI 3-Kγ PI 3-Kα and PI 3-Kβ, respectively) in an enzymatic assay with an EC50 = 16 nM for PI 3-Kδ and 2.7 µM for PI 3-Kγ in a cell based assay. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions. This compound, at concentrations between 370 nM and 10 µM, leads to a dose-dependent decrease in E-selectin expression. Furthermore, it is not cytotoxic to HUVEC cells.
          Catalogue Number526559
          Brand Family Calbiochem®
          Synonyms2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one, PI 3-K Inhibitor XIV
          References
          ReferencesWilliams, O., et al. 2010. Chem Biol. 17, 123.
          Product Information
          FormWhite solid
          Hill FormulaC₂₅H₂₁N₇O₂
          Chemical formulaC₂₅H₂₁N₇O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity>95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Regulatory Review
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          526559

          References

          Reference overview
          Williams, O., et al. 2010. Chem Biol. 17, 123.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-June-2011 RFH
          Synonyms2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one, PI 3-K Inhibitor XIV
          DescriptionA cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kδ (IC50 = 7 nM, 1300 nM, 85000 nM, and 740 nM for PI 3-Kδ, PI 3-Kγ PI 3-Kα and PI 3-Kβ, respectively) in an enzymatic assay with an EC50 = 16 nM for PI 3-Kδ and 2.7 µM for PI 3-Kγ in a cell based assay. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions. This compound, at concentrations between 370 nM and 10 µM, leads to a dose-dependent decrease in E-selectin expression. Furthermore, it is not cytotoxic to HUVEC cells.
          FormWhite solid
          Chemical formulaC₂₅H₂₁N₇O₂
          Structure formulaStructure formula
          Purity>95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesWilliams, O., et al. 2010. Chem Biol. 17, 123.