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14-558-D | PI3 kinase (p120Υ)

20 μg  
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      Replacement Information
      Catalogue Number14-558-D
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPI3 kinase (p120Υ)
      OverviewRecombinant human p120Υ, full length, with N-terminal His-tag,
      Product Information
      Presentation25 mM Tris, pH 8.0, 69 mM NaCl, 1.35 mM KCl, 0.025% Tween-20, 3 mM DTT, and 50% glycerol
      ApplicationRecombinant human p120Υ, full length, with N-terminal His-tag, for use in enzyme kinetics, screening inhibitors, and selectivity profiling.
      Key Applications
      • Kinase Assay
      Biological Information
      Concentration0.22 mg/ml
      SourceSf9 insect cells
      Specific Activity1226 pmol/min/μg.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
      Gene Symbol
      • PIK3CG
      • p110-gamma
      • PI3-kinase
      • PIK3
      • PI3K
      • PI3Kgamma
      • PTDINS-3-kinase
      • PI3CG
      • p120-PI3K
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P48736 # 3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5- triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.
      SIZE: 1102 amino acids; 126454 Da
      SUBUNIT: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.
      TISSUE SPECIFICITY: Pancreas, skeletal muscle, liver and heart.
      SIMILARITY: SwissProt: P48736 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
      Molecular Weight130 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Kinase assay: 45 min followed by incubation with the Kinase Detection reagent (50 μL) for 55 min.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for > 6 month at –80°C from date of receipt.
      Packaging Information
      Material Size20 μg
      Transport Information
      Supplemental Information