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33-038 | PI 3-Kinase Class II HTRF Assay

384 wells  Kit capacity: 384 wells
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      Replacement Information
      Catalogue Number33-038
      Brand Family Upstate
      Trade Name
      • HTRF
      • Upstate
      DescriptionPI 3-Kinase Class II HTRF Assay
      Product Information
      • Reaction Buffer (4X)
      • DM A Detection Reagent
      • DM C Detection Reagent
      • DM D Detection Reagent
      • Phosphatidylinositol (1mM)
      • Phosphatidylserine (1mM)
      • Stop Reagent C
      Detection methodHTRF
      ApplicationOne-plate kit (384 well plate) of reagents for performing PI 3-Kinase (Class II) 4-step HTRF assays. Suitable for the following Kinases: PI3KC2α, PI3KC2β & PI3KC2γ.
      Key Applications
      • Kinase Assay
      Biological Information
      Species Reactivity
      • Human
      • Mouse
      Analytes Available
      • PI 3-Kinase Class II
      Entrez Gene Number
      Entrez Gene SummaryPhosphoinositide 3-kinase-C2 proteins generate phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. This protein belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.
      Gene Symbol
      • PI3KC2α
      • PI3KC2β
      • PI3KC2γ
      Target Sub-FamilyPI3K/PI4K
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions12 months at -70°C
      Packaging Information
      Material Size384 wells
      Material PackageKit capacity: 384 wells
      Transport Information
      Supplemental Information

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      33-039 PI 3-Kinase Class II HTRF Assay Show Pricing & Availability

      Product Families

      Related Products By: Brand Facete


      Life Science Research > Protein Detection and Quantification > Activity Assays > Kinase Assays
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Enzyme Assay Kits and Reagents