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14-916 | PEK Protein, active, 10 µg

10 µg  Also available in 250 µg size - call for pricing and availability and reference catalog number 14-916M when ordering the 250 µg size.
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      This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
      Catalogue Number14-916
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPEK Protein, active, 10 µg
      OverviewN-terminal, 6His-tagged, recombinant human PEK, amino acids 536-end.
      Product Information
      Presentation50 mM Tris-HCl, pH 7.5, 0.3 M NaCl, 0.1 mM EGTA, 0.03 % Brij-35, 270 mM sucrose, 0.1% 2-mercaptoethanol, 1mM benzamidine, 200 μM PMSF
      ApplicationActive, N-terminal, 6His-tagged, recombinant human PEK, amino acids 536-end. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman PEK expressed by baculovirus in Sf21 insect cells
      Entrez Gene Number
      Gene Symbol
      • PERK
      • WRS
      • EIF2AK3
      • DKFZp781H1925
      Purification MethodImmobilized metal affinity chromatography (IMAC)
      UniProt Number
      UniProt SummaryFUNCTION: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 (By similarity).

      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein.

      TISSUE SPECIFICITY: Ubiquitous. A high level expression is seen in secretory tissues.

      PTM: Autophosphorylated. N-glycosylated (By similarity).

      SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. Contains 1 protein kinase domain.
      Molecular Weight71 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of RSRSRSRSRSRSRSR. For Specific Activity Data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250 µg size - call for pricing and availability and reference catalog number 14-916M when ordering the 250 µg size.
      Transport Information
      Supplemental Information