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12-401 | PDKtide

1 mg  
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      Replacement Information
      Catalogue Number12-401
      Brand Family Upstate
      Trade Name
      • Upstate
      Product Information
      Presentation1 mg in 200 μL of sterile, distilled water.
      ApplicationPDKtide primarily used in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryPyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.
      Gene Symbol
      • PDK1
      • PDPK1
      Protein TargetPDK1
      Target Sub-FamilyAGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15118 # Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
      SIZE: 436 amino acids; 49244 Da
      SUBCELLULAR LOCATION: Mitochondrion matrix.
      TISSUE SPECIFICITY: Expressed predominantly in the heart.
      SIMILARITY: SwissProt: Q15118 ## Belongs to the PDK/BCKDK protein kinase family. & Contains 1 histidine kinase domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated as a substrate for PDK.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsLyophilized: 2 years at 4°C. Rehydrated: 1 year at -20°C.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information

      Related Products & Applications

      Product Families


      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates