521235 PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem

521235
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₈N₂O₃ 210644-62-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      521235-5MG
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      Stocked 
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively).
          Catalogue Number521235
          Brand Family Calbiochem®
          Synonyms(Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid, mTOR Inhibitor X, Aurora Kinase Inhibitor IV, VEGFR Tyrosine Kinase Inhibitor XXVII, VEGFR2 Kinase Inhibitor XXV
          References
          ReferencesGodl, K., et al. 2005. Cancer Res. 65, 6919.
          Laird, A.D., et al. 2002. FASEB J. 16, 681.
          Krystal, G.W., et al. 2001. Cancer Res. 61, 3660.
          Smolich, B.D., et al. 2001. Blood 97, 1413.
          Laird, A.D., et al. 2000. Cancer Res. 60, 4152.
          Shaheen, R.M., et al. 1999. Cancer Res. 59, 5412.
          Sun, L. et al. 1999. J. Med. Chem. 42, 5120.
          Product Information
          CAS number210644-62-5
          FormDark yellow solid
          Hill FormulaC₁₈H₁₈N₂O₃
          Chemical formulaC₁₈H₁₈N₂O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22-36/37/38

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          521235

          References

          Reference overview
          Godl, K., et al. 2005. Cancer Res. 65, 6919.
          Laird, A.D., et al. 2002. FASEB J. 16, 681.
          Krystal, G.W., et al. 2001. Cancer Res. 61, 3660.
          Smolich, B.D., et al. 2001. Blood 97, 1413.
          Laird, A.D., et al. 2000. Cancer Res. 60, 4152.
          Shaheen, R.M., et al. 1999. Cancer Res. 59, 5412.
          Sun, L. et al. 1999. J. Med. Chem. 42, 5120.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-April-2009 RFH
          Synonyms(Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid, mTOR Inhibitor X, Aurora Kinase Inhibitor IV, VEGFR Tyrosine Kinase Inhibitor XXVII, VEGFR2 Kinase Inhibitor XXV
          DescriptionA cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively).
          FormDark yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number210644-62-5
          Chemical formulaC₁₈H₁₈N₂O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          ReferencesGodl, K., et al. 2005. Cancer Res. 65, 6919.
          Laird, A.D., et al. 2002. FASEB J. 16, 681.
          Krystal, G.W., et al. 2001. Cancer Res. 61, 3660.
          Smolich, B.D., et al. 2001. Blood 97, 1413.
          Laird, A.D., et al. 2000. Cancer Res. 60, 4152.
          Shaheen, R.M., et al. 1999. Cancer Res. 59, 5412.
          Sun, L. et al. 1999. J. Med. Chem. 42, 5120.