513040 PD 174265 - CAS 216163-53-0 - Calbiochem

513040
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₅BrN₄O 216163-53-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      513040-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).
          Catalogue Number513040
          Brand Family Calbiochem®
          Synonyms4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline
          References
          ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.
          Product Information
          CAS number216163-53-0
          ATP CompetitiveY
          FormYellow solid
          Hill FormulaC₁₇H₁₅BrN₄O
          Chemical formulaC₁₇H₁₅BrN₄O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetEGFR tyrosine kinase activity
          Primary Target IC<sub>50</sub>450 pM against EGF receptor (EGFR) tyrosine kinase activity
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          513040

          References

          Reference overview
          Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-February-2012 RFH
          Synonyms4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline
          DescriptionA potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 0.45 nM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number216163-53-0
          Chemical formulaC₁₇H₁₅BrN₄O
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.