234490 PD 153035 - CAS 153436-54-5 - Calbiochem
An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 25 pM; Ki = 6 pM).
More>> An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 25 pM; Ki = 6 pM). Less<<PD 153035 - CAS 153436-54-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
Overview
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Key Specifications Table
Empirical Formula | CAS # |
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C₁₆H₁₄BrN₃O₂ | 153436-54-5 |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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234490-1MG |
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Plastic ampoule | 1 mg |
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Description | |
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Overview | An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available. |
Catalogue Number | 234490 |
Brand Family | Calbiochem® |
Synonyms | AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32 |
References | |
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References | Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267. Fry, D.W., et al. 1994. Science 265, 1093. |
Applications |
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Biological Information | |
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Primary Target | EGFR |
Primary Target IC<sub>50</sub> | 25 pM |
Primary Target K<sub>i</sub> | 6 pM against epidermal growth factor receptor (EGFR) |
Purity | ≥97% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
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Materials Information |
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Safety Information according to GHS |
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Supplemental Information |
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Specifications |
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Documentation
SDS
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Certificates of Analysis
Title | Lot Number |
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234490 |
References
Reference overview |
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Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267. Fry, D.W., et al. 1994. Science 265, 1093. |
Technical Info
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JAK/STAT Signaling Research Focus |
Citations
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Data Sheet | ||||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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