513024 PD 151746 - CAS 179461-52-0 - Calbiochem

513024
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₁H₈FNO₂ 179461-52-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      513024-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for calpain-1 (Cat. Nos. 208712 and 208713) over calpain-2 (Cat. Nos. 208715 and 208718) (Ki values: 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide-induced apoptosis.
          Catalogue Number513024
          Brand Family Calbiochem®
          Synonyms3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid
          References
          ReferencesSquier, M.K., et al. 1999. J. Cell Physiol. 178, 311.
          Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
          Product Information
          CAS number179461-52-0
          ATP CompetitiveN
          FormOrange solid
          Hill FormulaC₁₁H₈FNO₂
          Chemical formulaC₁₁H₈FNO₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetcalpain-1
          Primary Target K<sub>i</sub>260 nM against calpain-1
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          513024

          References

          Reference overview
          Squier, M.K., et al. 1999. J. Cell Physiol. 178, 311.
          Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.

          Citations

          Title
        • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2011 RFH
          Synonyms3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid
          DescriptionA cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for µ-calpain (Calpain I) over m-calpain (Calpain II) (Ki values, 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide induced apoptosis.
          FormOrange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number179461-52-0
          Chemical formulaC₁₁H₈FNO₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml) or Methanol (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Toxicity Standard Handling
          ReferencesSquier, M.K., et al. 1999. J. Cell Physiol. 178, 311.
          Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
          Citation
        • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.