513020 PD 145065 - CAS 153049-49-1 - Calbiochem

513020
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₅₂H₆₃N₇O₁₀ · 2Na 153049-49-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      513020-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewA highly potent but non-selective endothelin receptor antagonist [IC50 = 4 nM for the ETA receptor (rabbit renal artery vascular smooth muscle cells); IC50 = 15 nM for the ETB receptor (rat cerebellum)].
          Catalogue Number513020
          Brand Family Calbiochem®
          References
          ReferencesHan, H.K., et al. 1998. Life Sci. 63, 1599.
          Allcock, G.H., et al. 1995. Br. J. Pharmacol. 116, 2482.
          Wellings, R.P., et al. 1994. Eur. J. Pharmacol. 256, 201.
          Cody, W.L., et al. 1993. Med. Chem. Res. 3, 154.
          Doherty, A.M., et al. 1993. J. Cardiovasc. Pharmacol. 22, S98 (Suppl.).
          Product Information
          CAS number153049-49-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₅₂H₆₃N₇O₁₀ · 2Na
          Chemical formulaC₅₂H₆₃N₇O₁₀ · 2Na
          ReversibleN
          Applications
          Biological Information
          Primary TargetEndothelin receptor antagonist
          Primary Target IC<sub>50</sub>4 nM against endothelin receptor (ETA receptor) in rabbit renal artery vascular smooth muscle cells; 15 nM for the ETB receptor (rat cerebellum)
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceAc-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 4 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          513020

          References

          Reference overview
          Han, H.K., et al. 1998. Life Sci. 63, 1599.
          Allcock, G.H., et al. 1995. Br. J. Pharmacol. 116, 2482.
          Wellings, R.P., et al. 1994. Eur. J. Pharmacol. 256, 201.
          Cody, W.L., et al. 1993. Med. Chem. Res. 3, 154.
          Doherty, A.M., et al. 1993. J. Cardiovasc. Pharmacol. 22, S98 (Suppl.).
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-August-2008 RFH
          DescriptionA highly potent but non-selective endothelin receptor antagonist [IC50 = 4 nM for the ETA receptor (rabbit renal artery vascular smooth muscle cells); IC50 = 15 nM for ETB receptor (rat cerebellum)].
          FormWhite solid
          CAS number153049-49-1
          Chemical formulaC₅₂H₆₃N₇O₁₀ · 2Na
          Peptide SequenceAc-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine)
          Purity≥98% by HPLC
          SolubilityPhosphate buffer, pH 7.5 (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 4 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesHan, H.K., et al. 1998. Life Sci. 63, 1599.
          Allcock, G.H., et al. 1995. Br. J. Pharmacol. 116, 2482.
          Wellings, R.P., et al. 1994. Eur. J. Pharmacol. 256, 201.
          Cody, W.L., et al. 1993. Med. Chem. Res. 3, 154.
          Doherty, A.M., et al. 1993. J. Cardiovasc. Pharmacol. 22, S98 (Suppl.).