493800 | PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem

493800
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₈N₂O₂ 90417-38-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      493800-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA potent inhibitor poly(ADP-ribose) polymerase (PARP; IC50 = 0.40 µM). Has been shown to potentiate the cytotoxicity of the DNA-methylating agent MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide] and ionizing irradiation in murine L210 leukemia cells.
          Catalogue Number493800
          Brand Family Calbiochem®
          Synonyms8-Hydroxy-2-methylquinazoline-4-one
          References
          ReferencesDelaney, C.A., et al. 2000. Clin. Cancer Res. 6, 2860.
          Boulton, S., et al. 1999. Carcinogenesis 20, 199.
          Bowman, K.J., et al. 1998. Br. J. Cancer 78, 1269.
          Griffin, R.J., et al. 1998. J. Med. Chem. 41, 5247.
          Griffin, R.J., et al. 1996. Pharm. Sci. 2, 43.
          Boulton, S., et al. 1995. Br. J. Cancer 72, 849.
          Griffin, R.J., et al. 1995. Anticancer Drug Res. 10, 507.
          Product Information
          CAS number90417-38-2
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₉H₈N₂O₂
          Chemical formulaC₉H₈N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPARP
          Primary Target IC<sub>50</sub>0.4 µM against poly(ADP-ribose) polymerase (PARP)
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          493800

          References

          Reference overview
          Delaney, C.A., et al. 2000. Clin. Cancer Res. 6, 2860.
          Boulton, S., et al. 1999. Carcinogenesis 20, 199.
          Bowman, K.J., et al. 1998. Br. J. Cancer 78, 1269.
          Griffin, R.J., et al. 1998. J. Med. Chem. 41, 5247.
          Griffin, R.J., et al. 1996. Pharm. Sci. 2, 43.
          Boulton, S., et al. 1995. Br. J. Cancer 72, 849.
          Griffin, R.J., et al. 1995. Anticancer Drug Res. 10, 507.

          Brochure

          Title
          Biologics 33.1 ( 1.37 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-August-2008 RFH
          Synonyms8-Hydroxy-2-methylquinazoline-4-one
          DescriptionA potent poly(ADP-ribose) polymerase (PARP) inhibitor (IC50 = 400 nM) that potentiates the cytotoxicity of various DNA-active agents, including the DNA-methylating compound MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide], the DNA strand break-inducing drug temozolomide, topotecan, bleomycin, and ionizing radiation in murine L1210 leukemia cells, Chinese hamster ovary cells, and in a variety of human tumor cell lines.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number90417-38-2
          Chemical formulaC₉H₈N₂O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (25 mg/ml). This solution can be further diluted 1:100 in tissue culture medium before use.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesDelaney, C.A., et al. 2000. Clin. Cancer Res. 6, 2860.
          Boulton, S., et al. 1999. Carcinogenesis 20, 199.
          Bowman, K.J., et al. 1998. Br. J. Cancer 78, 1269.
          Griffin, R.J., et al. 1998. J. Med. Chem. 41, 5247.
          Griffin, R.J., et al. 1996. Pharm. Sci. 2, 43.
          Boulton, S., et al. 1995. Br. J. Cancer 72, 849.
          Griffin, R.J., et al. 1995. Anticancer Drug Res. 10, 507.