419800 | PARP Inhibitor IV, IQD - CAS 1188540 - Calbiochem

419800
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₇NO₂ 5154-02-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      419800-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA potent, cell-permeable inhibitor of poly(ADP-ribose) polymerase (PARS; IC50 = 390 nM). Blocks nitric oxide-induced neuronal toxicity.
          Catalogue Number419800
          Brand Family Calbiochem®
          Synonyms1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinoline, 1,5-Isoquinolinediol
          References
          ReferencesKamoshima, W., et al. 1997. Neurochem. Int. 30, 305.
          Dalamu, M., et al. 1996. Exp. Cell Res. 228, 14.
          Zhang, J., et al. 1994. Science 263, 687.
          Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569.
          Product Information
          CAS number5154-02-9
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₉H₇NO₂
          Chemical formulaC₉H₇NO₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPoly(ADP-ribose) polymerase (PARS)
          Primary Target IC<sub>50</sub>390 nM against poly(ADP-ribose) polymerase (PARS)
          Purity≥98% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          419800

          References

          Reference overview
          Kamoshima, W., et al. 1997. Neurochem. Int. 30, 305.
          Dalamu, M., et al. 1996. Exp. Cell Res. 228, 14.
          Zhang, J., et al. 1994. Science 263, 687.
          Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569.

          Brochure

          Title
          Biologics 33.1 ( 1.37 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-May-2009 JSW
          Synonyms1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinoline, 1,5-Isoquinolinediol
          DescriptionA potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number5154-02-9
          Chemical formulaC₉H₇NO₂
          Structure formulaStructure formula
          Purity≥98% by NMR
          SolubilityDMSO (30 mg/ml), 100 mM NaOH (5 mg/ml), or Methanol (8 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKamoshima, W., et al. 1997. Neurochem. Int. 30, 305.
          Dalamu, M., et al. 1996. Exp. Cell Res. 228, 14.
          Zhang, J., et al. 1994. Science 263, 687.
          Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569.