300270 | PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem

300270
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₂₆N₂O₂ 129075-73-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      300270-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.
          Catalogue Number300270
          Brand Family Calbiochem®
          Synonyms3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline
          References
          ReferencesEliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
          Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
          Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.
          Product Information
          CAS number129075-73-6
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₈H₂₆N₂O₂
          Chemical formulaC₁₈H₂₆N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPARP
          Primary Target IC<sub>50</sub>40 nM
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          300270

          References

          Reference overview
          Eliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
          Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
          Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.

          Brochure

          Title
          Biologics 33.1 ( 1.37 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-June-2008 RFH
          Synonyms3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline
          DescriptionA very potent and selective poly(ADP-ribose)polymerase (PARP) inhibitor (IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.
          FormOff-white solid
          CAS number129075-73-6
          Chemical formulaC₁₈H₂₆N₂O₂
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Harmful
          ReferencesEliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
          Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
          Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.