505758 | Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem

505758
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₁₄N₅O₁₃P₃ 71997-40-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05758.0001
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          Glass bottle 25 mg
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          Description
          OverviewA 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
          Catalogue Number505758
          Brand Family Calbiochem®
          SynonymsPurinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
          References
          ReferencesVergani, A., et al. 2013. Diabetes 62, 1665.
          DellʹAntonio, G., et al. 2002. Arthritis Rheum. 46, 3378.
          Wiley, J.S., et al. 1994. Br. J. Pharmacol. 112, 946.
          Murgia, M., et al. 1992. J. Biol. Chem. 268, 8199.
          Product Information
          CAS number71997-40-5
          FormWhite powder
          Hill FormulaC₁₀H₁₄N₅O₁₃P₃
          Chemical formulaC₁₀H₁₄N₅O₁₃P₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetP2X₇
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Vergani, A., et al. 2013. Diabetes 62, 1665.
          DellʹAntonio, G., et al. 2002. Arthritis Rheum. 46, 3378.
          Wiley, J.S., et al. 1994. Br. J. Pharmacol. 112, 946.
          Murgia, M., et al. 1992. J. Biol. Chem. 268, 8199.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-August-2013 JSW
          SynonymsPurinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
          DescriptionA 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
          FormWhite powder
          CAS number71997-40-5
          Chemical formulaC₁₀H₁₄N₅O₁₃P₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityH₂O (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesVergani, A., et al. 2013. Diabetes 62, 1665.
          DellʹAntonio, G., et al. 2002. Arthritis Rheum. 46, 3378.
          Wiley, J.S., et al. 1994. Br. J. Pharmacol. 112, 946.
          Murgia, M., et al. 1992. J. Biol. Chem. 268, 8199.