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499050 | Osteocalcin, Bovine Bone

499050
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      499050-100UG
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          Glass bottle 100 μg
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          Description
          OverviewSingle chain vitamin K-dependent protein produced by osteoblasts. Osteocalcin purified from bovine bone. Binds to phospholipid vesicles in the presence of Ca2+ (Kd = 6 µM). Also binds hydroxylapatite. A good marker of bone turnover. May play a role in bone mineralization, bone resorption, and bone formation.
          Catalogue Number499050
          Brand Family Calbiochem®
          SynonymsBone-Gla-Protein, BGP
          References
          ReferencesCarter, S.D., et al. 1996. J. Anim. Sci. 74, 2719.
          Watson, K.E., et al. 1994. J. Clin. Invest. 93, 2106.
          Tracy, R.P., et al. 1990. J. Bone Min. Res. 5, 451.
          Gendreau, M.A., et al. 1989. J. Biol. Chem. 264, 6972.
          Product Information
          FormLiquid
          FormulationIn 75 mM NaCl, 10 mM sodium phosphate buffer, pH 7.4.
          Hill FormulaC₂₆₃H₃₇₂N₆₆O₈₂S₂
          Chemical formulaC₂₆₃H₃₇₂N₆₆O₈₂S₂
          PI4.0 - 4.5
          Applications
          Biological Information
          Purity≥98% by SDS-PAGE
          Physicochemical Information
          Peptide SequenceH-Tyr-Leu-Asp-His-Trp-Leu-Gly-Ala-Pro-Ala-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Lys-Arg-Gla-Val-Cys²³-Gla-Leu-Asn-Pro-Asp-Cys²⁹-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val-OH (disulfide bond: 23 → 29)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          499050

          References

          Reference overview
          Carter, S.D., et al. 1996. J. Anim. Sci. 74, 2719.
          Watson, K.E., et al. 1994. J. Clin. Invest. 93, 2106.
          Tracy, R.P., et al. 1990. J. Bone Min. Res. 5, 451.
          Gendreau, M.A., et al. 1989. J. Biol. Chem. 264, 6972.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-August-2008 RFH
          SynonymsBone-Gla-Protein, BGP
          DescriptionSingle chain vitamin K-dependent protein produced by osteoblasts. Osteocalcin purified from bovine bone. Binds to phospholipid vesicles in the presence of Ca2+ (Kd = 6 µM). Also binds hydroxylapatite. Possible role in bone mineralization, bone resorption, and bone formation. Note: Gla corresponds to γ-carboxyglutamic acid.
          FormLiquid
          FormulationIn 75 mM NaCl, 10 mM sodium phosphate buffer, pH 7.4.
          Chemical formulaC₂₆₃H₃₇₂N₆₆O₈₂S₂
          Peptide SequenceH-Tyr-Leu-Asp-His-Trp-Leu-Gly-Ala-Pro-Ala-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Lys-Arg-Gla-Val-Cys²³-Gla-Leu-Asn-Pro-Asp-Cys²⁹-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val-OH (disulfide bond: 23 → 29)
          Purity≥98% by SDS-PAGE
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesCarter, S.D., et al. 1996. J. Anim. Sci. 74, 2719.
          Watson, K.E., et al. 1994. J. Clin. Invest. 93, 2106.
          Tracy, R.P., et al. 1990. J. Bone Min. Res. 5, 451.
          Gendreau, M.A., et al. 1989. J. Biol. Chem. 264, 6972.