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AG774 | Orexin-A, control peptide for AB3098

100 µg  
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      Replacement Information
      Catalogue NumberAG774
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionOrexin-A, control peptide for AB3098
      OverviewOrexin-A control peptide.

      Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus (1). Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is an 130 aa peptide with a putative 33 aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis (1). These neuropeptides bind and activate two closely related Orexin receptors--G protein coupled receptors (GPCRs) OX1R and OX2R.
      Product Information
      PresentationLiquid in PBS, pH 7.5
      Key Applications
      • Peptide Inhibition Assay
      Application NotesBlocking peptide for AB3098.

      Optimal working concentration must be determined by the end user.
      Biological Information
      Concentration1 mg/mL
      Source18 amino acid peptide from the amino terminus of mouse Orexin-A.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a hypothalamic neuropeptide precusor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
      Gene Symbol
      • HCRT
      • Hypocretin
      • OX
      • orexin
      • Hcrt
      • PPOX
      • PPORX
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O43612 # Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
      SIZE: 131 amino acids; 13363 Da
      SUBCELLULAR LOCATION: Rough endoplasmic reticulum (By similarity). Cytoplasmic vesicle (By similarity). Cell junction, synapse (By similarity). Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses (By similarity).
      TISSUE SPECIFICITY: Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
      PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides.
      DISEASE: SwissProt: O43612 # Defects in HCRT are a cause of narcolepsy [MIM:161400]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.
      SIMILARITY: SwissProt: O43612 ## Belongs to the orexin family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      OREXIN-A CONTROL PEPTIDE (MOUSE) -2734738 2734738


      Reference overviewPub Med ID
      Novel localization of orexin A in the tubular cytotypes of the rat testis.
      Simona Tafuri,Roberta Lo Muto,Luigi Michele Pavone,Salvatore Valiante,Anna Costagliola,Norma Staiano,Alfredo Vittoria
      Regulatory peptides 164 2010

      Show Abstract
      20619297 20619297
      Expression of orexin A and its receptor 1 in the vestibular glands of the cattle genital tract.
      Luigi Michele Pavone,Simona Tafuri,Luigi Avallone,Norma Staiano,Alfredo Vittoria
      Anatomical record (Hoboken, N.J. : 2007) 292 2009

      Show Abstract
      19089887 19089887
      Expression of orexin A and its receptor 1 in the rat epididymis.
      Simona Tafuri,Luigi M Pavone,Roberta Lo Muto,Matilde Basile,Emilia Langella,Enrica Fiorillo,Luigi Avallone,Norma Staiano,Alfredo Vittoria
      Regulatory peptides 155 2009

      Show Abstract
      19328827 19328827
      Expression of orexin A and its receptor 1 in the bovine urethroprostatic complex.
      Finizia Russo, Luigi Michele Pavone, Simona Tafuri, Luigi Avallone, Norma Staiano, Alfredo Vittoria
      Anatomical record (Hoboken, N.J. : 2007) 291 169-74 2008

      Show Abstract
      18213704 18213704
      Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
      Sakurai, T, et al.
      Cell, 92: 573-85 (1998) 1998

      Show Abstract
      9491897 9491897

      Data Sheet