532999 Orai1 Inhibitor, AnCoA4 - Calbiochem

532999
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₁₈O₆

      Pricing & Availability

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      5.32999.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable, non-toxic, tricyclic chromone-fused analog that directly binds to the C-terminus region of Orai 1 and reduces its binding to STIM1 and blocks Ca2+ influx through the store operated calcium (SOC) channel (EC50 = 880 nM). Its binding to Orai 1 is localized to the region that controls channel gating and interaction with STIM1. Does not affect voltage-gated Ca2+ channels even at higher concentrations (~ 10 µM). Shown to be more effective if administered before STIM1 begins interacting with Orai 1. Also shown to inhibit the expression genes involved in T cell activation and blocks Jurkat T cell proliferation (~ 10 µM). Reduces lymphohistiocytic inflammation without causing any neutrophil and tissue damage.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number532999
          Brand Family Calbiochem®
          SynonymsCRAC Inhibitor II
          References
          ReferencesSadaghiani, A.M., et al. 2014. Chem. Biol. 21, 1278.
          Product Information
          FormPale yellow solid
          Hill FormulaC₂₂H₁₈O₆
          Chemical formulaC₂₂H₁₈O₆
          ReversibleY
          Applications
          Biological Information
          Primary TargetOrail1
          Purity≥96% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Orai1 Inhibitor, AnCoA4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Sadaghiani, A.M., et al. 2014. Chem. Biol. 21, 1278.

          Brochure

          Title
          Neuroscience Solutions for productive research

          Technical Info

          Title
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          White Paper: Further considerations of antibody validation and usage. (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2015 JSW
          SynonymsCRAC Inhibitor II
          DescriptionA cell-permeable, non-toxic, tricyclic chromone-fused analog that directly binds to the C-terminus region of Orai 1 and reduces its binding to STIM1 and blocks Ca2+ influx through the store operated calcium (SOC) channel (EC50 = 880 nM). Its binding to Orai 1 is localized to the region that controls channel gating and interaction with STIM1. Does not affect voltage-gated Ca2+ channels even at higher concentrations (~ 10 µM). Shown to be more effective if administered before STIM1 begins interacting with Orai 1. Also shown to inhibit the expression genes involved in T cell activation and blocks Jurkat T cell proliferation (~ 10 µM). Reduces lymphohistiocytic inflammation without causing any neutrophil and tissue damage.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₁₈O₆
          Purity≥96% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSadaghiani, A.M., et al. 2014. Chem. Biol. 21, 1278.