459620 Okadaic Acid, Sodium Salt - Calbiochem

459620
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₄₄H₆₇O₁₃ · Na

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      459620-25UG
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          Alu drum 25 μg
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          Description
          OverviewWater-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.
          Catalogue Number459620
          Brand Family Calbiochem®
          References
          ReferencesGjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363.
          Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995.
          Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
          Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
          Kreienbuhl, P., et al. 1992. Blood 80, 2911.
          Normura, M., et al. 1992. Biochemistry 31, 11915.
          Song, Q., et al. 1992. J. Cell Physiol. 153, 550.
          Tada, Y., et al. 1992. Immunopharmacol. 24, 17.
          Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
          Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
          Cohen, P., and Cohen, P.T.W. 1989. J. Biol. Chem. 254 21435.
          Haystead, T.A. et al. 1989. Nature 337, 78.
          Product Information
          ATP CompetitiveN
          FormWhite solid - colorless film
          Hill FormulaC₄₄H₆₇O₁₃ · Na
          Chemical formulaC₄₄H₆₇O₁₃ · Na
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationOkadaic Acid, Sodium Salt, is a water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.
          Biological Information
          Primary TargetPP1, PP2
          Primary Target IC<sub>50</sub>10-15 nM, 0.1 nM against protein phosphatase 1, protein phosphatase 2A, respectively
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 23/24/25-38

          Toxic by inhalation, in contact with skin and if swallowed.
          Irritating to skin.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          459620

          References

          Reference overview
          Gjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363.
          Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995.
          Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
          Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
          Kreienbuhl, P., et al. 1992. Blood 80, 2911.
          Normura, M., et al. 1992. Biochemistry 31, 11915.
          Song, Q., et al. 1992. J. Cell Physiol. 153, 550.
          Tada, Y., et al. 1992. Immunopharmacol. 24, 17.
          Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
          Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
          Cohen, P., and Cohen, P.T.W. 1989. J. Biol. Chem. 254 21435.
          Haystead, T.A. et al. 1989. Nature 337, 78.

          Brochure

          Title
          Protein Phosphatases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-September-2014 JSW
          DescriptionWater-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.
          FormWhite solid - colorless film
          Chemical formulaC₄₄H₆₇O₁₃ · Na
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (20 mg/ml), Ethanol (20 mg/ml), or H₂O (1 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Toxic
          ReferencesGjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363.
          Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995.
          Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
          Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
          Kreienbuhl, P., et al. 1992. Blood 80, 2911.
          Normura, M., et al. 1992. Biochemistry 31, 11915.
          Song, Q., et al. 1992. J. Cell Physiol. 153, 550.
          Tada, Y., et al. 1992. Immunopharmacol. 24, 17.
          Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
          Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
          Cohen, P., and Cohen, P.T.W. 1989. J. Biol. Chem. 254 21435.
          Haystead, T.A. et al. 1989. Nature 337, 78.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Phosphatase Inhibitors