538241 Nur77-p38 Interaction Inhibitor, PDNPA - Calbiochem

538241
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₃₄O₅

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.38241.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable phenylacetate based compound that specifically blocks the Nur77-p38α interaction by directly targeting the ligand-binding domain of Nur77 (~1 to 10 µM) and impedes Nur77 phosphorylation by p38α. Does neither modulate p38α kinase activity nor affects the stability of the p38α-Nur77 complex. Inhibits p65 binding to DNA and blocks LPS-induced (100 ng/ml) NF-κB activity in RAW264.7 cells (IC50 = 1.6 µM), but does not affect the interaction between Nur77 and p65. Shown to reduce IL-6 concentration and prolong the lifespan of wild type mice treated with LPS. Also increases the survival rate of wild-type mice subjected to cecal ligation and puncture (CLP)-induced sepsis.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number538241
          Brand Family Calbiochem®
          SynonymsPentyl 2-(3,5-dihydroxy-2-nonanoylphenyl)acetate, NR4A1 Inhibitor, PDNPA, TR3-p38 Interaction Inhibitor, PDNPA
          References
          ReferencesLi, L., et al. 2015. Nat. Chem. Biol. 11, 339.
          Product Information
          FormWhite solid
          Hill FormulaC₂₂H₃₄O₅
          Chemical formulaC₂₂H₃₄O₅
          ReversibleY
          Applications
          Biological Information
          Primary TargetNur77
          Primary Target IC<sub>50</sub>1.6 µ
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Nur77-p38 Interaction Inhibitor, PDNPA - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Li, L., et al. 2015. Nat. Chem. Biol. 11, 339.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-March-2017 JSW
          SynonymsPentyl 2-(3,5-dihydroxy-2-nonanoylphenyl)acetate, NR4A1 Inhibitor, PDNPA, TR3-p38 Interaction Inhibitor, PDNPA
          DescriptionA cell-permeable phenylacetate based compound that specifically blocks the Nur77-p38α interaction by directly targeting the ligand-binding domain of Nur77 (~1 to 10 µM) and impedes Nur77 phosphorylation by p38α. Does neither modulate p38α kinase activity nor affects the stability of the p38α-Nur77 complex. Inhibits p65 binding to DNA and blocks LPS-induced (100 ng/ml) NF-κB activity in RAW264.7 cells (IC50 = 1.6 µM), but does not affect the interaction between Nur77 and p65. Shown to reduce IL-6 concentration and prolong the lifespan of wild type mice treated with LPS. Also increases the survival rate of wild-type mice subjected to cecal ligation and puncture (CLP)-induced sepsis.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₃₄O₅
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLi, L., et al. 2015. Nat. Chem. Biol. 11, 339.